BDBM212273 6-(6-aminopyrazin-2-yl)-5-methyl-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine::US10342794, Example Ex.-4::US10828299, Example Ex.-4::US9290505, Ex.-4::US9504684, Ex.-4::US9931338, Ex.-4
SMILES: Cc1c(nc(Nc2ccc(cc2)N2CCN(CC2)C2COC2)c2nccn12)-c1cncc(N)n1
InChI Key: InChIKey=WFQLDXGNAYZMLS-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CD63 antigen (Homo sapiens (Human)) | BDBM212273 (6-(6-aminopyrazin-2-yl)-5-methyl-N-(4-(4-(oxetan-3...) | MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 157 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Gilead Sciences, Inc. US Patent | Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca... | US Patent US9290505 (2016) BindingDB Entry DOI: 10.7270/Q2TB15RT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM212273 (6-(6-aminopyrazin-2-yl)-5-methyl-N-(4-(4-(oxetan-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 44 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Gilead Sciences, Inc. US Patent | Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca... | US Patent US9290505 (2016) BindingDB Entry DOI: 10.7270/Q2TB15RT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM212273 (6-(6-aminopyrazin-2-yl)-5-methyl-N-(4-(4-(oxetan-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
KRONOS BIO, INC. US Patent | Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca... | US Patent US10828299 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM212273 (6-(6-aminopyrazin-2-yl)-5-methyl-N-(4-(4-(oxetan-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee | Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca... | Bioorg Med Chem 16: 8853-62 (2008) BindingDB Entry DOI: 10.7270/Q2K076M3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM212273 (6-(6-aminopyrazin-2-yl)-5-methyl-N-(4-(4-(oxetan-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca... | US Patent US10342794 (2019) BindingDB Entry DOI: 10.7270/Q2R49T3H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM212273 (6-(6-aminopyrazin-2-yl)-5-methyl-N-(4-(4-(oxetan-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 44 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca... | US Patent US9504684 (2016) BindingDB Entry DOI: 10.7270/Q2XS5TB7 | |||||||||||
More data for this Ligand-Target Pair |