BDBM212277 US9290505, 6-(5-aminopyridin-3-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine::US9504684, 6-(5-aminopyridin-3-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine

SMILES: Nc1cncc(c1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCOCC2)n1

InChI Key: InChIKey=WCLQGWQXRCNKHS-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 212277   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CD63 antigen (Homo sapiens (Human))	BDBM212277 (US9290505, 6-(5-aminopyridin-3-yl)-N-(4-morpholino...) Show SMILES Nc1cncc(c1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCOCC2)n1 Show InChI InChI=1S/C21H21N7O/c22-16-11-15(12-23-13-16)19-14-28-6-5-24-21(28)20(26-19)25-17-1-3-18(4-2-17)27-7-9-29-10-8-27/h1-6,11-14H,7-10,22H2,(H,25,26)	MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	101	n/a	n/a	n/a	n/a	7.0	n/a
Gilead Sciences, Inc. US Patent					Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...				US Patent US9290505 (2016) BindingDB Entry DOI: 10.7270/Q2TB15RT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212277 (US9290505, 6-(5-aminopyridin-3-yl)-N-(4-morpholino...) Show SMILES Nc1cncc(c1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCOCC2)n1 Show InChI InChI=1S/C21H21N7O/c22-16-11-15(12-23-13-16)19-14-28-6-5-24-21(28)20(26-19)25-17-1-3-18(4-2-17)27-7-9-29-10-8-27/h1-6,11-14H,7-10,22H2,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	7.0	25
Gilead Sciences, Inc. US Patent					Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...				US Patent US9504684 (2016) BindingDB Entry DOI: 10.7270/Q2XS5TB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212277 (US9290505, 6-(5-aminopyridin-3-yl)-N-(4-morpholino...) Show SMILES Nc1cncc(c1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCOCC2)n1 Show InChI InChI=1S/C21H21N7O/c22-16-11-15(12-23-13-16)19-14-28-6-5-24-21(28)20(26-19)25-17-1-3-18(4-2-17)27-7-9-29-10-8-27/h1-6,11-14H,7-10,22H2,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	7.0	n/a
Gilead Sciences, Inc. US Patent					Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...				US Patent US9290505 (2016) BindingDB Entry DOI: 10.7270/Q2TB15RT
					More data for this Ligand-Target Pair