BDBM212404 US9290507, II-17

SMILES: COCCCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2ccc(o2)C(C)(C)C)ccc1C

InChI Key: InChIKey=BMSGGODTVOHPOI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 212404   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM212404 (US9290507, II-17) Show SMILES COCCCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2ccc(o2)C(C)(C)C)ccc1C Show InChI InChI=1S/C31H39N7O3/c1-22-7-8-24(33-30(39)28-9-10-29(41-28)31(2,3)4)18-27(22)38-21-26(34-35-38)23-17-25(20-32-19-23)37-14-12-36(13-15-37)11-6-16-40-5/h7-10,17-21H,6,11-16H2,1-5H3,(H,33,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description In a dilution series 10 uL/well of test substance solution are placed in a multiwell plate. The dilution series is selected so that generally a range...				US Patent US9290507 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F1H
					More data for this Ligand-Target Pair