BDBM213214 N2-(1-Acryloyl-4-piperidinyl)-6-(4-morpholinylmethyl)-N4-[1,3]thiazolo[5,4-b]pyridin-2-yl-2,4-pyrimidinediamine (3)

SMILES: C=CC(=O)N1CCC(CC1)Nc1nc(CN2CCOCC2)cc(Nc2nc3cccnc3s2)n1

InChI Key: InChIKey=MHAJTIYNCRZABX-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 213214   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interlukin-2-inducible tyrosine kinase (Itk) (Homo sapiens (Human))	BDBM213214 (N2-(1-Acryloyl-4-piperidinyl)-6-(4-morpholinylmeth...) Show SMILES C=CC(=O)N1CCC(CC1)Nc1nc(CN2CCOCC2)cc(Nc2nc3cccnc3s2)n1 Show InChI InChI=1S/C23H28N8O2S/c1-2-20(32)31-8-5-16(6-9-31)25-22-26-17(15-30-10-12-33-13-11-30)14-19(28-22)29-23-27-18-4-3-7-24-21(18)34-23/h2-4,7,14,16H,1,5-6,8-13,15H2,(H2,25,26,27,28,29)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...				J Biol Chem 288: 28195-206 (2013) Article DOI: 10.1074/jbc.M113.474114 BindingDB Entry DOI: 10.7270/Q2ZW1JSK
					More data for this Ligand-Target Pair