BDBM21372 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide::CHEMBL222188::Piperazinehexanamide derivative, 10
SMILES: O=C(CCCCCN1CCN(CC1)c1ccccc1)NC1CCCc2ccccc12
InChI Key: InChIKey=OPNMLXKOFJADTH-UHFFFAOYSA-N
Data: 7 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM21372 (6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydrona...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 65.6 | -10.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Universita degli Studi di Bari | Assay Description IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti... | J Med Chem 50: 4214-21 (2007) Article DOI: 10.1021/jm070487n BindingDB Entry DOI: 10.7270/Q20000CJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM21372 (6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydrona...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 65.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Bari Curated by ChEMBL | Assay Description Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells | J Med Chem 47: 6616-24 (2004) Article DOI: 10.1021/jm049702f BindingDB Entry DOI: 10.7270/Q2RX9BKX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM21372 (6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydrona...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 77.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Bari | Assay Description IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti... | J Med Chem 50: 4214-21 (2007) Article DOI: 10.1021/jm070487n BindingDB Entry DOI: 10.7270/Q20000CJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM21372 (6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydrona...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 77.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Bari Curated by ChEMBL | Assay Description Displacement of [3H]ketanserin from 5HT2A receptor in Wistar Han rat cortex membranes | J Med Chem 47: 6616-24 (2004) Article DOI: 10.1021/jm049702f BindingDB Entry DOI: 10.7270/Q2RX9BKX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM21372 (6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydrona...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 128 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Bari | Assay Description IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti... | J Med Chem 50: 4214-21 (2007) Article DOI: 10.1021/jm070487n BindingDB Entry DOI: 10.7270/Q20000CJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM21372 (6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydrona...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 128 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Bari Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from 5HT1A receptor in Wistar Han rat hippocampal membranes | J Med Chem 47: 6616-24 (2004) Article DOI: 10.1021/jm049702f BindingDB Entry DOI: 10.7270/Q2RX9BKX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM21372 (6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydrona...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Bari | Assay Description IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti... | J Med Chem 50: 4214-21 (2007) Article DOI: 10.1021/jm070487n BindingDB Entry DOI: 10.7270/Q20000CJ | |||||||||||
More data for this Ligand-Target Pair |