BDBM21375 6-[4-(2-cyanophenyl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide::CHEMBL221513::Piperazinehexanamide derivative, 13

SMILES: O=C(CCCCCN1CCN(CC1)c1ccccc1C#N)NC1CCCc2ccccc12

InChI Key: InChIKey=GKCVNAHJIZRKPK-UHFFFAOYSA-N

Data: 7 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 21375   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM21375 (6-[4-(2-cyanophenyl)piperazin-1-yl]-N-(1,2,3,4-tet...) Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1C#N)NC1CCCc2ccccc12 Show InChI InChI=1S/C27H34N4O/c28-21-23-10-4-6-14-26(23)31-19-17-30(18-20-31)16-7-1-2-15-27(32)29-25-13-8-11-22-9-3-5-12-24(22)25/h3-6,9-10,12,14,25H,1-2,7-8,11,13,15-20H2,(H,29,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Bari					Assay Description IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...				J Med Chem 50: 4214-21 (2007) Article DOI: 10.1021/jm070487n BindingDB Entry DOI: 10.7270/Q20000CJ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM21375 (6-[4-(2-cyanophenyl)piperazin-1-yl]-N-(1,2,3,4-tet...) Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1C#N)NC1CCCc2ccccc12 Show InChI InChI=1S/C27H34N4O/c28-21-23-10-4-6-14-26(23)31-19-17-30(18-20-31)16-7-1-2-15-27(32)29-25-13-8-11-22-9-3-5-12-24(22)25/h3-6,9-10,12,14,25H,1-2,7-8,11,13,15-20H2,(H,29,32)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from 5HT1A receptor in Wistar Han rat hippocampal membranes				J Med Chem 47: 6616-24 (2004) Article DOI: 10.1021/jm049702f BindingDB Entry DOI: 10.7270/Q2RX9BKX
					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM21375 (6-[4-(2-cyanophenyl)piperazin-1-yl]-N-(1,2,3,4-tet...) Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1C#N)NC1CCCc2ccccc12 Show InChI InChI=1S/C27H34N4O/c28-21-23-10-4-6-14-26(23)31-19-17-30(18-20-31)16-7-1-2-15-27(32)29-25-13-8-11-22-9-3-5-12-24(22)25/h3-6,9-10,12,14,25H,1-2,7-8,11,13,15-20H2,(H,29,32)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	48.7	-10.4	n/a	n/a	n/a	n/a	n/a	7.4	37
Universita degli Studi di Bari					Assay Description IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...				J Med Chem 50: 4214-21 (2007) Article DOI: 10.1021/jm070487n BindingDB Entry DOI: 10.7270/Q20000CJ
					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM21375 (6-[4-(2-cyanophenyl)piperazin-1-yl]-N-(1,2,3,4-tet...) Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1C#N)NC1CCCc2ccccc12 Show InChI InChI=1S/C27H34N4O/c28-21-23-10-4-6-14-26(23)31-19-17-30(18-20-31)16-7-1-2-15-27(32)29-25-13-8-11-22-9-3-5-12-24(22)25/h3-6,9-10,12,14,25H,1-2,7-8,11,13,15-20H2,(H,29,32)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	48.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells				J Med Chem 47: 6616-24 (2004) Article DOI: 10.1021/jm049702f BindingDB Entry DOI: 10.7270/Q2RX9BKX
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM21375 (6-[4-(2-cyanophenyl)piperazin-1-yl]-N-(1,2,3,4-tet...) Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1C#N)NC1CCCc2ccccc12 Show InChI InChI=1S/C27H34N4O/c28-21-23-10-4-6-14-26(23)31-19-17-30(18-20-31)16-7-1-2-15-27(32)29-25-13-8-11-22-9-3-5-12-24(22)25/h3-6,9-10,12,14,25H,1-2,7-8,11,13,15-20H2,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	265	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Bari					Assay Description IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...				J Med Chem 50: 4214-21 (2007) Article DOI: 10.1021/jm070487n BindingDB Entry DOI: 10.7270/Q20000CJ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM21375 (6-[4-(2-cyanophenyl)piperazin-1-yl]-N-(1,2,3,4-tet...) Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1C#N)NC1CCCc2ccccc12 Show InChI InChI=1S/C27H34N4O/c28-21-23-10-4-6-14-26(23)31-19-17-30(18-20-31)16-7-1-2-15-27(32)29-25-13-8-11-22-9-3-5-12-24(22)25/h3-6,9-10,12,14,25H,1-2,7-8,11,13,15-20H2,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from 5HT2A receptor in Wistar Han rat cortex membranes				J Med Chem 47: 6616-24 (2004) Article DOI: 10.1021/jm049702f BindingDB Entry DOI: 10.7270/Q2RX9BKX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM21375 (6-[4-(2-cyanophenyl)piperazin-1-yl]-N-(1,2,3,4-tet...) Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1C#N)NC1CCCc2ccccc12 Show InChI InChI=1S/C27H34N4O/c28-21-23-10-4-6-14-26(23)31-19-17-30(18-20-31)16-7-1-2-15-27(32)29-25-13-8-11-22-9-3-5-12-24(22)25/h3-6,9-10,12,14,25H,1-2,7-8,11,13,15-20H2,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Bari					Assay Description IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...				J Med Chem 50: 4214-21 (2007) Article DOI: 10.1021/jm070487n BindingDB Entry DOI: 10.7270/Q20000CJ
					More data for this Ligand-Target Pair