BDBM214746 Rhodanines, 34A

SMILES: [O-]C(=O)c1ccc(o1)-c1ccc(cc1)-c1ccc(\C=C2/SC(=S)N(CCc3c[nH]cn3)C2=O)o1

InChI Key: InChIKey=SWVZQDQTKBSAPH-NHDPSOOVSA-M

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 214746   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Microtubule-associated protein tau (TAU)(2N4R) (Homo sapiens (Human))	BDBM214746 (Rhodanines, 34A) Show SMILES [O-]C(=O)c1ccc(o1)-c1ccc(cc1)-c1ccc(\C=C2/SC(=S)N(CCc3c[nH]cn3)C2=O)o1 Show InChI InChI=1S/C24H17N3O5S2/c28-22-21(34-24(33)27(22)10-9-16-12-25-13-26-16)11-17-5-6-18(31-17)14-1-3-15(4-2-14)19-7-8-20(32-19)23(29)30/h1-8,11-13H,9-10H2,(H,25,26)(H,29,30)/p-1/b21-11-	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	7.4	n/a
The Ohio State University					Assay Description The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...				J Biol Chem 288: 32599-611 (2013) Article DOI: 10.1074/jbc.M113.503474 BindingDB Entry DOI: 10.7270/Q2R49PMK
					More data for this Ligand-Target Pair