Found 18 hits for monomerid = 21492 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
TGF-beta receptor type-1 T204D
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| PDB Article PubMed
| n/a | n/a | 59 | n/a | 40 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories
| Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... |
J Med Chem 51: 2302-2306 (2008)
Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| PDB Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
Curated by ChEMBL
| Assay Description Inhibition of TGFBR1 |
J Med Chem 55: 9946-57 (2012)
Article DOI: 10.1021/jm301144g BindingDB Entry DOI: 10.7270/Q2DF6SCJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Procter & Gamble Company
US Patent
| Assay Description Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ... |
US Patent US9144538 (2015)
BindingDB Entry DOI: 10.7270/Q22806DV |
More data for this Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
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| PDB PubMed
| n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a |
Biogen Inc
Curated by ChEMBL
| Assay Description Dissociation constant for TGF-beta receptor type I |
Bioorg Med Chem Lett 13: 4355-9 (2003)
BindingDB Entry DOI: 10.7270/Q29886FH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
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| n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Inc
Curated by ChEMBL
| Assay Description Inhibition of Transforming growth factor beta-1 receptor (TbetaRI) autophosphorylation |
Bioorg Med Chem Lett 13: 4355-9 (2003)
BindingDB Entry DOI: 10.7270/Q29886FH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mixed lineage kinase 7
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB
NCI pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description Inhibition of MLK7 |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
The Lilly Research Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux) |
J Med Chem 46: 3953-6 (2003)
Article DOI: 10.1021/jm0205705 BindingDB Entry DOI: 10.7270/Q2RV0N38 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
The Lilly Research Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Mitogen-activated protein kinase p38 |
J Med Chem 46: 3953-6 (2003)
Article DOI: 10.1021/jm0205705 BindingDB Entry DOI: 10.7270/Q2RV0N38 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
The Lilly Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Transforming growth factor (TGF) beta-1 receptor (T204D mutation) autophosphorylation in Sf9 cells |
J Med Chem 46: 3953-6 (2003)
Article DOI: 10.1021/jm0205705 BindingDB Entry DOI: 10.7270/Q2RV0N38 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
The Lilly Research Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3) |
J Med Chem 46: 3953-6 (2003)
Article DOI: 10.1021/jm0205705 BindingDB Entry DOI: 10.7270/Q2RV0N38 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 5.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 |
Bioorg Med Chem Lett 14: 3585-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.065 BindingDB Entry DOI: 10.7270/Q23R0SCK |
More data for this Ligand-Target Pair | |
TGF-beta receptor type II
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory
Curated by ChEMBL
| Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells |
J Med Chem 49: 2138-42 (2006)
Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase ABL2
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | n/a | 1.87E+3 | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Binding affinity to human ARG |
J Med Chem 51: 7898-914 (2008)
Article DOI: 10.1021/jm8011036 BindingDB Entry DOI: 10.7270/Q2WS8T4C |
More data for this Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
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| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of TGFBR1 |
J Med Chem 51: 7898-914 (2008)
Article DOI: 10.1021/jm8011036 BindingDB Entry DOI: 10.7270/Q2WS8T4C |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of TGFR1 |
Eur J Med Chem 44: 4259-65 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.008 BindingDB Entry DOI: 10.7270/Q2BC3ZM9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM21492
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
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| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Procter & Gamble Company
US Patent
| Assay Description A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ... |
US Patent US9138393 (2015)
BindingDB Entry DOI: 10.7270/Q2GF0S8J |
More data for this Ligand-Target Pair | |