BDBM215302 US9296736, 263

SMILES: C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CNS(=O)(=O)c2cccs2)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1

InChI Key: InChIKey=NIXWEXNCFVDWBK-JWAZIOJDSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 215302   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2 and p53 (Homo sapiens (Human))	BDBM215302 (US9296736, 263) Show SMILES C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CNS(=O)(=O)c2cccs2)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C29H30Cl2N2O5S2/c1-29(16-25(34)35)15-23(20-4-2-5-22(31)14-20)27(19-9-11-21(30)12-10-19)33(28(29)36)24(18-7-8-18)17-32-40(37,38)26-6-3-13-39-26/h2-6,9-14,18,23-24,27,32H,7-8,15-17H2,1H3,(H,34,35)/t23-,24-,27-,29-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	25
Amgen INC. US Patent					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				US Patent US9296736 (2016) BindingDB Entry DOI: 10.7270/Q29022M2
					More data for this Ligand-Target Pair