BDBM215311 US9296736, 273

SMILES: C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CN(c2ccccc2F)S(C)(=O)=O)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1

InChI Key: InChIKey=AVWZEUWSQPZNGD-CYOCIPQASA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 215311   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2 and p53 (Homo sapiens (Human))	BDBM215311 (US9296736, 273) Show SMILES C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CN(c2ccccc2F)S(C)(=O)=O)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C32H33Cl2FN2O5S/c1-32(18-29(38)39)17-25(22-6-5-7-24(34)16-22)30(21-12-14-23(33)15-13-21)37(31(32)40)28(20-10-11-20)19-36(43(2,41)42)27-9-4-3-8-26(27)35/h3-9,12-16,20,25,28,30H,10-11,17-19H2,1-2H3,(H,38,39)/t25-,28-,30-,32-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	25
Amgen INC. US Patent					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				US Patent US9296736 (2016) BindingDB Entry DOI: 10.7270/Q29022M2
					More data for this Ligand-Target Pair