null

SMILES: C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CS(=O)(=O)CC(F)(F)F)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1

InChI Key: InChIKey=BDYAVVVJDLYQJB-HLMLHLEXSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 215355   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM215355 (US9296736, 323 | US9593129, Example 323) Show SMILES C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CS(=O)(=O)CC(F)(F)F)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 Show InChI InChI=1S/C27H28Cl2F3NO5S/c1-26(13-23(34)35)12-21(18-3-2-4-20(29)11-18)24(17-7-9-19(28)10-8-17)33(25(26)36)22(16-5-6-16)14-39(37,38)15-27(30,31)32/h2-4,7-11,16,21-22,24H,5-6,12-15H2,1H3,(H,34,35)/t21-,22-,24-,26-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. US Patent					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				US Patent US9593129 (2017) BindingDB Entry DOI: 10.7270/Q20P1232
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM215355 (US9296736, 323 | US9593129, Example 323) Show SMILES C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CS(=O)(=O)CC(F)(F)F)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 Show InChI InChI=1S/C27H28Cl2F3NO5S/c1-26(13-23(34)35)12-21(18-3-2-4-20(29)11-18)24(17-7-9-19(28)10-8-17)33(25(26)36)22(16-5-6-16)14-39(37,38)15-27(30,31)32/h2-4,7-11,16,21-22,24H,5-6,12-15H2,1H3,(H,34,35)/t21-,22-,24-,26-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	25
Amgen INC. US Patent					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				US Patent US9296736 (2016) BindingDB Entry DOI: 10.7270/Q29022M2
					More data for this Ligand-Target Pair