BDBM215374 US9296736, 352::US9593129, Example 352

SMILES: C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CS(=O)(=O)C2CCC2)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1

InChI Key: InChIKey=BEMKVBQFXJENBW-GCMXZSHTSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 215374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (aa 1-188) (Homo sapiens (Human))	BDBM215374 (US9296736, 352 | US9593129, Example 352) Show SMILES C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CS(=O)(=O)C2CCC2)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 Show InChI InChI=1S/C29H33Cl2NO5S/c1-29(16-26(33)34)15-24(20-4-2-5-22(31)14-20)27(19-10-12-21(30)13-11-19)32(28(29)35)25(18-8-9-18)17-38(36,37)23-6-3-7-23/h2,4-5,10-14,18,23-25,27H,3,6-9,15-17H2,1H3,(H,33,34)/t24-,25-,27-,29-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. US Patent					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				US Patent US9593129 (2017) BindingDB Entry DOI: 10.7270/Q20P1232
					More data for this Ligand-Target Pair
MDM2 and p53 (Homo sapiens (Human))	BDBM215374 (US9296736, 352 | US9593129, Example 352) Show SMILES C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CS(=O)(=O)C2CCC2)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 Show InChI InChI=1S/C29H33Cl2NO5S/c1-29(16-26(33)34)15-24(20-4-2-5-22(31)14-20)27(19-10-12-21(30)13-11-19)32(28(29)35)25(18-8-9-18)17-38(36,37)23-6-3-7-23/h2,4-5,10-14,18,23-25,27H,3,6-9,15-17H2,1H3,(H,33,34)/t24-,25-,27-,29-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	25
Amgen INC. US Patent					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				US Patent US9296736 (2016) BindingDB Entry DOI: 10.7270/Q29022M2
					More data for this Ligand-Target Pair