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BDBM215556 US9296745, 112

SMILES: FC(F)(F)c1cccc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1

InChI Key: InChIKey=VNJFBNKNUSWEDT-YQTOOIBONA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 215556   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215556
PNG
(US9296745, 112)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1 |r|
Show InChI InChI=1/C22H23F3N6O/c23-22(24,25)17-7-3-6-15(26-17)19-27-16-8-9-18(28-20(16)29-19)31-12-4-5-14(13-31)21(32)30-10-1-2-11-30/h3,6-9,14H,1-2,4-5,10-13H2,(H,27,28,29)/t14-/s2
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KEGG

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 9.23n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair