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BDBM21575 2-{5-chloro-1'-[(2,5-difluorophenyl)methyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-2,2',5'-trione}acetic acid::Spiro-indolinone analogue, 67

SMILES: OC(=O)CN1C(=O)C2(CC(=O)N(Cc3cc(F)ccc3F)C2=O)c2cc(Cl)ccc12

InChI Key: InChIKey=SWCNYWLKCRDUOM-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21575   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM21575
PNG
(2-{5-chloro-1'-[(2,5-difluorophenyl)methyl]-1,2-di...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3cc(F)ccc3F)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H13ClF2N2O5/c21-11-1-4-15-13(6-11)20(18(29)24(15)9-17(27)28)7-16(26)25(19(20)30)8-10-5-12(22)2-3-14(10)23/h1-6H,7-9H2,(H,27,28)
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21n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...


J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair