Found 42 hits for monomerid = 21641 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neprilysin
(Oryctolagus cuniculus (rabbit)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 4 | -11.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
CNRS
| Assay Description NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp... |
J Med Chem 45: 1477-86 (2002)
Article DOI: 10.1021/jm0005454 BindingDB Entry DOI: 10.7270/Q2T72FQ1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neprilysin
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article
| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated for inhibition of recombinant human neprilysin(NEP). |
Bioorg Med Chem Lett 6: 2437-2440 (1996)
Article DOI: 10.1016/0960-894X(96)00448-9 BindingDB Entry DOI: 10.7270/Q2JS9QD0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity towards enkephalinase (metalloendopeptidase, E.C.3.4.24.11) of rat kidney |
J Med Chem 28: 1208-16 (1985)
BindingDB Entry DOI: 10.7270/Q2VM4CVV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Angiotensin-Converting Enzyme
(Rattus norvegicus) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS
| Assay Description Specific activity of ACE was assayed in black 96-well microplates with or without various concentrations of inhibitors. N-Cbz-Phe-His-Leu was added, ... |
J Med Chem 45: 1477-86 (2002)
Article DOI: 10.1021/jm0005454 BindingDB Entry DOI: 10.7270/Q2T72FQ1 |
More data for this Ligand-Target Pair | |
Thermolysin
(Bacillus thermoproteolyticus) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description Inhibitory constant against thermolysin. |
J Med Chem 35: 1671-84 (1992)
BindingDB Entry DOI: 10.7270/Q2DR2W3S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Endothelin-converting enzyme 1 (ECE1)
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS
| Assay Description ECE activity was performed in black 96-well microplates with recombinant human ECE-1c (hECE-1c). The hECE-1c was preincubated with or without increa... |
J Med Chem 45: 1477-86 (2002)
Article DOI: 10.1021/jm0005454 BindingDB Entry DOI: 10.7270/Q2T72FQ1 |
More data for this Ligand-Target Pair | |
Angiotensin II receptor
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma US Inc.
Curated by ChEMBL
| Assay Description Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA |
ACS Med Chem Lett 10: 86-91 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00462 |
More data for this Ligand-Target Pair | |
Endothelin-converting enzyme 2 (ECE-2)
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| >1.00E+5 | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaleads
| Assay Description Inhibitory assay against ECE-2. |
J Biol Chem 285: 34390-400 (2010)
Article DOI: 10.1074/jbc.M110.120576 BindingDB Entry DOI: 10.7270/Q29P307K |
More data for this Ligand-Target Pair | |
Thermolysin
(Bacillus thermoproteolyticus) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 1.00E+14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Marburg
Curated by ChEMBL
| Assay Description pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L) |
J Med Chem 45: 1585-97 (2002)
Article DOI: 10.1021/jm011039x BindingDB Entry DOI: 10.7270/Q25B057T |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neprilysin
(Oryctolagus cuniculus (rabbit)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description Inhibitory concentration was evaluated by Inhibiting 50% of Neutral endopeptidase enzyme (NEP) activity using 20 nM [3H]-D-Ala2-Leu-enkephalin as sub... |
J Med Chem 36: 87-94 (1993)
BindingDB Entry DOI: 10.7270/Q26972NK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description Tested in vitro for the inhibition against neutral endopeptidase (NEP) from rat kidney |
J Med Chem 36: 3829-33 (1994)
BindingDB Entry DOI: 10.7270/Q2125RRG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Angiotensin-converting enzyme
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description Inhibitory concentration was evaluated by Inhibiting 50% of Angiotensin I converting enzyme activity using 50 microM N-Cbz-Phe-His-Leu as substrate |
J Med Chem 36: 87-94 (1993)
BindingDB Entry DOI: 10.7270/Q26972NK |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description Inhibition of human NEP-mediated amyloid beta hydrolysis |
Eur J Med Chem 79: 184-93 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.009 BindingDB Entry DOI: 10.7270/Q27H1M34 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neprilysin
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharmaceuticals Corporation
Curated by ChEMBL
| Assay Description Inhibition of neutral endopeptidase |
J Med Chem 40: 495-505 (1997)
Article DOI: 10.1021/jm960582o BindingDB Entry DOI: 10.7270/Q2ZC81Z3 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thermolysin
(Bacillus thermoproteolyticus) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharmaceuticals Corporation
Curated by ChEMBL
| Assay Description Inhibitory concentration required to inhibit thermolysin |
J Med Chem 40: 495-505 (1997)
Article DOI: 10.1021/jm960582o BindingDB Entry DOI: 10.7270/Q2ZC81Z3 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against neutral endopeptidase (NEP 24.11) from rat kidney cortex membranes |
Bioorg Med Chem Lett 4: 539-542 (1994)
Article DOI: 10.1016/S0960-894X(01)80150-5 BindingDB Entry DOI: 10.7270/Q2736QV0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of neutral endopeptidase from rat kidney. |
Bioorg Med Chem Lett 6: 65-70 (1996)
Article DOI: 10.1016/0960-894X(95)00551-4 BindingDB Entry DOI: 10.7270/Q2BZ66J9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neprilysin
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of Neutral Endopeptidase |
Bioorg Med Chem Lett 6: 1487-1490 (1996)
Article DOI: 10.1016/S0960-894X(96)00255-7 BindingDB Entry DOI: 10.7270/Q2B27VSQ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Endothelin-converting enzyme 1 (ECE1)
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition against recombinant human Endothelin converting enzyme 1 activity |
Bioorg Med Chem Lett 7: 1059-1064 (1997)
Article DOI: 10.1016/S0960-894X(97)00159-5 BindingDB Entry DOI: 10.7270/Q2WH2QGK |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of neutral endopeptidase 24.11(NEP) |
Bioorg Med Chem Lett 7: 1059-1064 (1997)
Article DOI: 10.1016/S0960-894X(97)00159-5 BindingDB Entry DOI: 10.7270/Q2WH2QGK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition against neutral endopeptidase 24.11 (NEP) in rat kidney cortex membrane |
Bioorg Med Chem Lett 4: 2673-2676 (1994)
Article DOI: 10.1016/S0960-894X(01)80694-6 BindingDB Entry DOI: 10.7270/Q2X34XXT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neprilysin
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against neutral endopeptidase |
Bioorg Med Chem Lett 4: 2715-2720 (1994)
Article DOI: 10.1016/S0960-894X(01)80703-4 BindingDB Entry DOI: 10.7270/Q2SB467B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of enkephalinase purified from rat kidney. |
J Med Chem 28: 1158-69 (1985)
BindingDB Entry DOI: 10.7270/Q20C4WB5 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatum |
J Med Chem 32: 2519-26 (1989)
BindingDB Entry DOI: 10.7270/Q2668DSV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description In vitro inhibition of Neutral endopeptidase (NEP) enzyme |
J Med Chem 37: 498-511 (1994)
BindingDB Entry DOI: 10.7270/Q2H70GF9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Endothelin-converting enzyme 1 (ECE1)
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1 |
J Med Chem 38: 2119-29 (1995)
BindingDB Entry DOI: 10.7270/Q2D79C2M |
More data for this Ligand-Target Pair | |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description Evaluation of in vitro inhibitory activity against Neutral endopeptidase |
J Med Chem 38: 5023-30 (1996)
BindingDB Entry DOI: 10.7270/Q26D5TMH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Biomedical Research
Curated by ChEMBL
| Assay Description In vitro inhibition of rat neutral endopeptidase |
J Med Chem 43: 488-504 (2000)
BindingDB Entry DOI: 10.7270/Q21G0MZR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Endothelin-converting enzyme 1 (ECE1)
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Biomedical Research
Curated by ChEMBL
| Assay Description In Vitro inhibition of recombinant human endothelin converting enzyme-1 |
J Med Chem 43: 488-504 (2000)
BindingDB Entry DOI: 10.7270/Q21G0MZR |
More data for this Ligand-Target Pair | |
Neprilysin
(Sus scrofa) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Dipartimento di Chimica
Curated by ChEMBL
| Assay Description Inhibition of pig kidney NEP by fluorimetry |
Bioorg Med Chem Lett 19: 4715-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.064 BindingDB Entry DOI: 10.7270/Q2GH9JWT |
More data for this Ligand-Target Pair | |
Angiotensin-converting enzyme
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description Inhibition of angiotensin I converting enzyme in silico |
J Med Chem 40: 3161-72 (1997)
Article DOI: 10.1021/jm970211n BindingDB Entry DOI: 10.7270/Q2MG7QPB |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma US Inc.
Curated by ChEMBL
| Assay Description Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass... |
ACS Med Chem Lett 10: 86-91 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00462 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description The compound was tested in vitro for inhibition of Neutral endopeptidase by using ANF(atrial natriuretic factor) as substrate |
J Med Chem 38: 1689-700 (1995)
BindingDB Entry DOI: 10.7270/Q2Z89BD0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neprilysin
(Oryctolagus cuniculus (rabbit)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against big ET-1 of Neutral endopeptidase |
J Med Chem 38: 2119-29 (1995)
BindingDB Entry DOI: 10.7270/Q2D79C2M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neprilysin
(Oryctolagus cuniculus (rabbit)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against Leu-enkeph of Neutral endopeptidase |
J Med Chem 38: 2119-29 (1995)
BindingDB Entry DOI: 10.7270/Q2D79C2M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrate |
J Med Chem 38: 1689-700 (1995)
BindingDB Entry DOI: 10.7270/Q2Z89BD0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description In vitro inhibition of rat neutral endopeptidase by using GAAP as substrate |
J Med Chem 38: 1689-700 (1995)
BindingDB Entry DOI: 10.7270/Q2Z89BD0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neprilysin
(Oryctolagus cuniculus (rabbit)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description Inhibition of enkephalinase activity in membranes prepared from rabbit |
J Med Chem 32: 2519-26 (1989)
BindingDB Entry DOI: 10.7270/Q2668DSV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Angiotensin-converting enzyme
(Oryctolagus cuniculus) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against angiotensin I converting enzyme (ACE) from rabbit lung |
J Med Chem 35: 602-8 (1992)
BindingDB Entry DOI: 10.7270/Q2QZ28ZD |
More data for this Ligand-Target Pair | |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description The compound was tested in vitro for its inhibitory activity against Enkephalinase enzyme |
J Med Chem 35: 602-8 (1992)
BindingDB Entry DOI: 10.7270/Q2QZ28ZD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | 25 |
R&D, Zambon Group Spa
| Assay Description Enzyme inhibition assay using neutrol endopeptiase EC 3.4.24.11 (NEP). |
J Enzym Inhib 12: 155-60 (1997)
Article DOI: 10.3109/14756369709035816 BindingDB Entry DOI: 10.7270/Q2FQ9V4F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM21641
(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)Show InChI InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description The compound was tested for its inhibitory activity against neutral endopeptidase (EC.3.4.24.111) in rat kidney |
Bioorg Med Chem Lett 3: 825-830 (1993)
Article DOI: 10.1016/S0960-894X(00)80674-5 BindingDB Entry DOI: 10.7270/Q22807J2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |