null

SMILES: OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(cc3)-n3cncn3)ccc12

InChI Key: InChIKey=AOZIYHRDHCZRJS-KRWDZBQOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 21774   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM21774 (2-[(1S)-5-{3-[4-(1H-1,2,4-triazol-1-yl)phenoxy]pro...) Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(cc3)-n3cncn3)ccc12 |r| Show InChI InChI=1S/C22H23N3O4/c26-22(27)13-17-3-2-16-12-20(8-9-21(16)17)29-11-1-10-28-19-6-4-18(5-7-19)25-15-23-14-24-25/h4-9,12,14-15,17H,1-3,10-11,13H2,(H,26,27)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	7.4	22
Bayer HealthCare Pharmaceuticals Corporation					Assay Description Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...				J Med Chem 50: 984-1000 (2007) Article DOI: 10.1021/jm061299k BindingDB Entry DOI: 10.7270/Q2NK3C93
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM21774 (2-[(1S)-5-{3-[4-(1H-1,2,4-triazol-1-yl)phenoxy]pro...) Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(cc3)-n3cncn3)ccc12 |r| Show InChI InChI=1S/C22H23N3O4/c26-22(27)13-17-3-2-16-12-20(8-9-21(16)17)29-11-1-10-28-19-6-4-18(5-7-19)25-15-23-14-24-25/h4-9,12,14-15,17H,1-3,10-11,13H2,(H,26,27)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	25
Bayer HealthCare Pharmaceuticals Corporation					Assay Description Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...				J Med Chem 50: 984-1000 (2007) Article DOI: 10.1021/jm061299k BindingDB Entry DOI: 10.7270/Q2NK3C93
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM21774 (2-[(1S)-5-{3-[4-(1H-1,2,4-triazol-1-yl)phenoxy]pro...) Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(cc3)-n3cncn3)ccc12 |r| Show InChI InChI=1S/C22H23N3O4/c26-22(27)13-17-3-2-16-12-20(8-9-21(16)17)29-11-1-10-28-19-6-4-18(5-7-19)25-15-23-14-24-25/h4-9,12,14-15,17H,1-3,10-11,13H2,(H,26,27)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article	n/a	n/a	n/a	n/a	9.09E+7	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at GST-tagged Homo sapiens (human) PPARdelta ligand binding domain after 2 hr by FRET assay				Citation and Details Article DOI: 10.1007/s00044-011-9599-z BindingDB Entry DOI: 10.7270/Q22J6FR8
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human))	BDBM21774 (2-[(1S)-5-{3-[4-(1H-1,2,4-triazol-1-yl)phenoxy]pro...) Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(cc3)-n3cncn3)ccc12 |r| Show InChI InChI=1S/C22H23N3O4/c26-22(27)13-17-3-2-16-12-20(8-9-21(16)17)29-11-1-10-28-19-6-4-18(5-7-19)25-15-23-14-24-25/h4-9,12,14-15,17H,1-3,10-11,13H2,(H,26,27)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article	n/a	n/a	n/a	n/a	1.82E+6	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Homo sapiens (human) PPARgamma expressed in mouse 3T3-L1 cells incubated for 2 days followed by compound wash out measured after ...				Citation and Details Article DOI: 10.1007/s00044-011-9599-z BindingDB Entry DOI: 10.7270/Q22J6FR8
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human))	BDBM21774 (2-[(1S)-5-{3-[4-(1H-1,2,4-triazol-1-yl)phenoxy]pro...) Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(cc3)-n3cncn3)ccc12 |r| Show InChI InChI=1S/C22H23N3O4/c26-22(27)13-17-3-2-16-12-20(8-9-21(16)17)29-11-1-10-28-19-6-4-18(5-7-19)25-15-23-14-24-25/h4-9,12,14-15,17H,1-3,10-11,13H2,(H,26,27)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	555	n/a	n/a	n/a	25
Bayer HealthCare Pharmaceuticals Corporation					Assay Description PPAR gamma activity was assessed by using the IRBA in mouse 3T3-L1 cells. This assay measures the ability of test compound to cause an increase in th...				J Med Chem 50: 984-1000 (2007) Article DOI: 10.1021/jm061299k BindingDB Entry DOI: 10.7270/Q2NK3C93
					More data for this Ligand-Target Pair