BindingDB PrimarySearch

BDBM21898 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol-4-ylmethyl)amino]quinoline-3-carbonitrile::CHEMBL436817::Cyanoquinoline, 11

SMILES: Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cnc[nH]4)cc23)C#N)cc1Cl

InChI Key: InChIKey=ONXROKMQGCSOMG-UHFFFAOYSA-N

Data: 13 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 21898
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM21898 (8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.2	30
Wyeth Research					Assay Description Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...				J Med Chem 50: 4728-45 (2007) Article DOI: 10.1021/jm070436q BindingDB Entry DOI: 10.7270/Q2891441
Wyeth Research					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM21898 (8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...				J Med Chem 50: 4728-45 (2007) Article DOI: 10.1021/jm070436q BindingDB Entry DOI: 10.7270/Q2891441
Wyeth Research					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM21898 (8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human PKCalpha by scintiplate assay				J Biol Chem 282: 33295-304 (2007) Article DOI: 10.1074/jbc.M703694200 BindingDB Entry DOI: 10.7270/Q2KS6RBP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM21898 (8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human Tpl2 by ELISA				J Biol Chem 282: 33295-304 (2007) Article DOI: 10.1074/jbc.M703694200 BindingDB Entry DOI: 10.7270/Q2KS6RBP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM21898 (8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human EGFR by ELISA				J Biol Chem 282: 33295-304 (2007) Article DOI: 10.1074/jbc.M703694200 BindingDB Entry DOI: 10.7270/Q2KS6RBP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Oryctolagus cuniculus (rabbit))	BDBM21898 (8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of rabbit MEK1 by ELISA				J Biol Chem 282: 33295-304 (2007) Article DOI: 10.1074/jbc.M703694200 BindingDB Entry DOI: 10.7270/Q2KS6RBP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM21898 (8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human Raf1				J Biol Chem 282: 33295-304 (2007) Article DOI: 10.1074/jbc.M703694200 BindingDB Entry DOI: 10.7270/Q2KS6RBP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM21898 (8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human p38alpha by ELISA				J Biol Chem 282: 33295-304 (2007) Article DOI: 10.1074/jbc.M703694200 BindingDB Entry DOI: 10.7270/Q2KS6RBP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM21898 (8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human Src by ELISA				J Biol Chem 282: 33295-304 (2007) Article DOI: 10.1074/jbc.M703694200 BindingDB Entry DOI: 10.7270/Q2KS6RBP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM21898 (8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human MK2 by scintiplate assay				J Biol Chem 282: 33295-304 (2007) Article DOI: 10.1074/jbc.M703694200 BindingDB Entry DOI: 10.7270/Q2KS6RBP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 6 (Homo sapiens (Human))	BDBM21898 (8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human MKK6 by ELISA				J Biol Chem 282: 33295-304 (2007) Article DOI: 10.1074/jbc.M703694200 BindingDB Entry DOI: 10.7270/Q2KS6RBP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM21898 (8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human IKK-beta by ELISA				J Biol Chem 282: 33295-304 (2007) Article DOI: 10.1074/jbc.M703694200 BindingDB Entry DOI: 10.7270/Q2KS6RBP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM21898 (8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of IL-1-beta-stimulated MMP3 in human RA-FLS cells by immunoblot analysis				J Biol Chem 282: 33295-304 (2007) Article DOI: 10.1074/jbc.M703694200 BindingDB Entry DOI: 10.7270/Q2KS6RBP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair