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BDBM21910 Cyanoquinoline, 23::N-{8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-3-cyanoquinolin-6-yl}-2-(1H-imidazol-4-yl)acetamide

SMILES: Fc1ccc(Nc2c(cnc3c(Br)cc(NC(=O)Cc4cnc[nH]4)cc23)C#N)cc1Cl

InChI Key: InChIKey=BCYGLDOHWRIBSY-UHFFFAOYSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21910   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM21910
PNG
(Cyanoquinoline, 23 | N-{8-bromo-4-[(3-chloro-4-flu...)
Show SMILES Fc1ccc(Nc2c(cnc3c(Br)cc(NC(=O)Cc4cnc[nH]4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C21H13BrClFN6O/c22-16-4-13(29-19(31)6-14-9-26-10-28-14)3-15-20(11(7-25)8-27-21(15)16)30-12-1-2-18(24)17(23)5-12/h1-5,8-10H,6H2,(H,26,28)(H,27,30)(H,29,31)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+3n/an/an/an/a7.230



Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...


J Med Chem 50: 4728-45 (2007)


Article DOI: 10.1021/jm070436q
BindingDB Entry DOI: 10.7270/Q2891441
More data for this
Ligand-Target Pair