BDBM21937 8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(2-phenyl-1H-imidazol-5-yl)methyl]amino}quinoline-3-carbonitrile::Cyanoquinoline, 48

SMILES: Fc1ccc(Nc2c(cnc3c(Br)cc(NCc4cnc([nH]4)-c4ccccc4)cc23)C#N)cc1Cl

InChI Key: InChIKey=GZBKHPDSJJYDPP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21937   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM21937 (8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(2-...) Show SMILES Fc1ccc(Nc2c(cnc3c(Br)cc(NCc4cnc([nH]4)-c4ccccc4)cc23)C#N)cc1Cl Show InChI InChI=1S/C26H17BrClFN6/c27-21-9-18(31-13-19-14-33-26(35-19)15-4-2-1-3-5-15)8-20-24(16(11-30)12-32-25(20)21)34-17-6-7-23(29)22(28)10-17/h1-10,12,14,31H,13H2,(H,32,34)(H,33,35)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...				J Med Chem 50: 4728-45 (2007) Article DOI: 10.1021/jm070436q BindingDB Entry DOI: 10.7270/Q2891441
					More data for this Ligand-Target Pair