Found 2 hits for monomerid = 21940 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Ghrelin receptor
(Homo sapiens (Human)) | BDBM21940
(Ghrelin)Show SMILES CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O |wU:166.168,203.207,151.153,133.135,67.68,77.79,26.25,113.115,11.11,97.99,178.182,185.190,189.194,wD:194.198,157.159,211.215,227.232,142.144,58.59,45.45,37.37,122.124,86.88,104.106,15.17,223.229,54.56,(58.89,-82.98,;57.56,-82.21,;57.56,-80.67,;56.23,-79.9,;56.23,-78.36,;54.89,-77.59,;54.89,-76.05,;53.56,-75.28,;52.22,-76.05,;53.56,-73.74,;52.22,-72.97,;52.22,-71.43,;53.56,-70.66,;54.89,-71.43,;54.89,-72.97,;56.23,-70.66,;56.23,-69.12,;57.56,-68.35,;57.56,-71.43,;58.89,-70.66,;58.89,-69.12,;60.23,-71.43,;61.56,-70.66,;50.89,-70.66,;50.89,-69.12,;49.56,-71.43,;48.22,-70.66,;46.89,-71.43,;46.89,-72.97,;48.22,-73.74,;48.22,-75.28,;46.89,-76.05,;45.56,-75.28,;45.56,-73.74,;48.22,-69.12,;49.56,-68.35,;46.89,-68.35,;46.89,-66.81,;48.22,-66.04,;48.22,-64.5,;49.56,-63.73,;46.89,-63.73,;45.56,-66.04,;45.56,-64.5,;44.22,-66.81,;42.89,-66.04,;42.89,-64.5,;41.55,-63.73,;41.55,-66.81,;41.55,-68.35,;40.22,-66.04,;40.06,-64.51,;38.55,-64.19,;37.78,-65.52,;38.81,-66.67,;38.49,-68.17,;39.64,-69.2,;37.03,-68.65,;35.88,-67.62,;36.2,-66.11,;35.06,-65.08,;35.38,-63.58,;34.24,-62.54,;36.85,-63.1,;34.42,-68.09,;34.1,-69.6,;33.28,-67.06,;31.81,-67.54,;31.49,-69.05,;30.03,-69.52,;28.78,-68.62,;27.53,-69.52,;28.01,-70.99,;29.55,-70.99,;30.67,-66.51,;29.2,-66.99,;30.99,-65,;29.84,-63.97,;28.38,-64.45,;27.23,-63.42,;25.77,-63.89,;24.62,-62.86,;25.45,-65.4,;30.16,-62.47,;31.63,-61.99,;29.02,-61.44,;29.34,-59.93,;30.8,-59.45,;31.12,-57.95,;32.59,-57.47,;32.91,-55.96,;34.37,-55.49,;34.69,-53.98,;35.52,-56.52,;28.19,-58.9,;26.73,-59.37,;28.51,-57.39,;27.37,-56.36,;25.9,-56.84,;24.76,-55.81,;25.58,-58.34,;27.69,-54.86,;29.15,-54.38,;26.54,-53.83,;26.87,-52.32,;28.33,-51.84,;28.65,-50.34,;30.11,-49.86,;30.43,-48.35,;31.26,-50.89,;25.72,-51.29,;24.26,-51.76,;26.04,-49.78,;24.9,-48.75,;23.43,-49.23,;22.29,-48.2,;20.82,-48.67,;19.68,-47.64,;20.5,-50.18,;25.22,-47.25,;26.68,-46.77,;24.07,-46.21,;24.39,-44.71,;25.86,-44.23,;26.18,-42.73,;27.64,-42.25,;27.96,-40.74,;29.43,-40.27,;29.75,-38.76,;30.57,-41.3,;23.25,-43.68,;21.78,-44.15,;23.57,-42.17,;22.42,-41.14,;20.96,-41.62,;19.81,-40.59,;18.35,-41.06,;17.21,-40.03,;15.74,-40.51,;22.74,-39.63,;24.21,-39.16,;21.6,-38.6,;21.92,-37.1,;23.38,-36.62,;23.7,-35.12,;25.17,-34.64,;25.49,-33.13,;26.31,-35.67,;20.77,-36.07,;19.31,-36.54,;21.1,-34.56,;19.95,-33.53,;18.49,-34.01,;17.34,-32.98,;20.27,-32.02,;21.74,-31.55,;19.13,-30.99,;19.45,-29.49,;20.91,-29.01,;21.23,-27.5,;22.7,-27.03,;23.02,-25.52,;24.48,-25.05,;18.3,-28.46,;16.84,-28.93,;18.62,-26.95,;17.48,-25.92,;16.01,-26.4,;14.87,-25.37,;13.4,-25.84,;12.26,-24.81,;10.79,-25.29,;17.8,-24.41,;19.26,-23.94,;16.65,-23.38,;15.15,-23.7,;14.38,-22.37,;15.41,-21.22,;16.81,-21.85,;18.15,-21.08,;19.48,-21.85,;18.15,-19.54,;16.9,-18.64,;17.38,-17.17,;18.92,-17.17,;19.39,-18.64,;20.86,-19.11,;21.18,-20.62,;22,-18.08,;21.68,-16.57,;20.22,-16.1,;22.83,-15.54,;24.29,-16.02,;22.51,-14.04,;23.65,-13.01,;25.12,-13.48,;26.26,-12.45,;27.73,-12.93,;28.87,-11.9,;30.33,-12.37,;23.33,-11.5,;21.87,-11.03,;24.48,-10.47,;24.16,-8.96,;22.69,-8.49,;21.66,-7.34,;20.15,-7.66,;22.14,-5.88,;25.3,-7.93,;26.76,-8.41,;24.98,-6.43,;26.12,-5.4,;27.59,-5.87,;28.73,-4.84,;30.2,-5.32,;30.52,-6.82,;31.34,-4.29,;25.8,-3.89,;24.34,-3.41,;26.95,-2.86,;28.46,-3.18,;29.23,-1.85,;28.19,-.7,;26.79,-1.33,;25.45,-.56,;24.12,-1.33,;25.45,.98,;26.79,1.75,;28.12,.98,;29.46,1.75,;30.79,.98,;32.12,1.75,;33.46,.98,;34.79,1.75,;33.46,-.56,;26.79,3.29,;28.12,4.06,;25.45,4.06,)| Show InChI InChI=1S/C149H249N47O42/c1-9-10-11-12-16-45-118(209)238-78-106(191-135(225)103(75-197)171-115(204)73-154)137(227)187-101(71-84-32-14-13-15-33-84)133(223)186-100(70-81(4)5)132(222)190-105(77-199)144(234)194-66-29-42-108(194)139(229)180-95(51-57-117(207)208)128(218)188-102(72-85-74-165-79-169-85)134(224)179-92(47-53-112(156)201)126(216)175-90(39-26-63-167-148(161)162)130(220)192-119(82(6)7)141(231)181-93(48-54-113(157)202)127(217)177-91(46-52-111(155)200)125(215)174-89(38-25-62-166-147(159)160)122(212)173-87(35-18-22-59-151)121(211)178-94(50-56-116(205)206)129(219)189-104(76-198)136(226)176-88(36-19-23-60-152)123(213)182-96(37-20-24-61-153)142(232)196-68-31-44-110(196)145(235)195-67-30-41-107(195)138(228)170-83(8)120(210)172-86(34-17-21-58-150)124(214)185-99(69-80(2)3)131(221)183-97(49-55-114(158)203)143(233)193-65-28-43-109(193)140(230)184-98(146(236)237)40-27-64-168-149(163)164/h13-15,32-33,74,79-83,86-110,119,197-199H,9-12,16-31,34-73,75-78,150-154H2,1-8H3,(H2,155,200)(H2,156,201)(H2,157,202)(H2,158,203)(H,165,169)(H,170,228)(H,171,204)(H,172,210)(H,173,212)(H,174,215)(H,175,216)(H,176,226)(H,177,217)(H,178,211)(H,179,224)(H,180,229)(H,181,231)(H,182,213)(H,183,221)(H,184,230)(H,185,214)(H,186,223)(H,187,227)(H,188,218)(H,189,219)(H,190,222)(H,191,225)(H,192,220)(H,205,206)(H,207,208)(H,236,237)(H4,159,160,166)(H4,161,162,167)(H4,163,164,168)/t83-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,119-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga... |
J Med Chem 43: 4370-6 (2000)
BindingDB Entry DOI: 10.7270/Q2T72GP0 |
More data for this
Ligand-Target Pair | |
Ghrelin receptor
(Homo sapiens (Human)) | BDBM21940
(Ghrelin)Show SMILES CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O |wU:166.168,203.207,151.153,133.135,67.68,77.79,26.25,113.115,11.11,97.99,178.182,185.190,189.194,wD:194.198,157.159,211.215,227.232,142.144,58.59,45.45,37.37,122.124,86.88,104.106,15.17,223.229,54.56,(58.89,-82.98,;57.56,-82.21,;57.56,-80.67,;56.23,-79.9,;56.23,-78.36,;54.89,-77.59,;54.89,-76.05,;53.56,-75.28,;52.22,-76.05,;53.56,-73.74,;52.22,-72.97,;52.22,-71.43,;53.56,-70.66,;54.89,-71.43,;54.89,-72.97,;56.23,-70.66,;56.23,-69.12,;57.56,-68.35,;57.56,-71.43,;58.89,-70.66,;58.89,-69.12,;60.23,-71.43,;61.56,-70.66,;50.89,-70.66,;50.89,-69.12,;49.56,-71.43,;48.22,-70.66,;46.89,-71.43,;46.89,-72.97,;48.22,-73.74,;48.22,-75.28,;46.89,-76.05,;45.56,-75.28,;45.56,-73.74,;48.22,-69.12,;49.56,-68.35,;46.89,-68.35,;46.89,-66.81,;48.22,-66.04,;48.22,-64.5,;49.56,-63.73,;46.89,-63.73,;45.56,-66.04,;45.56,-64.5,;44.22,-66.81,;42.89,-66.04,;42.89,-64.5,;41.55,-63.73,;41.55,-66.81,;41.55,-68.35,;40.22,-66.04,;40.06,-64.51,;38.55,-64.19,;37.78,-65.52,;38.81,-66.67,;38.49,-68.17,;39.64,-69.2,;37.03,-68.65,;35.88,-67.62,;36.2,-66.11,;35.06,-65.08,;35.38,-63.58,;34.24,-62.54,;36.85,-63.1,;34.42,-68.09,;34.1,-69.6,;33.28,-67.06,;31.81,-67.54,;31.49,-69.05,;30.03,-69.52,;28.78,-68.62,;27.53,-69.52,;28.01,-70.99,;29.55,-70.99,;30.67,-66.51,;29.2,-66.99,;30.99,-65,;29.84,-63.97,;28.38,-64.45,;27.23,-63.42,;25.77,-63.89,;24.62,-62.86,;25.45,-65.4,;30.16,-62.47,;31.63,-61.99,;29.02,-61.44,;29.34,-59.93,;30.8,-59.45,;31.12,-57.95,;32.59,-57.47,;32.91,-55.96,;34.37,-55.49,;34.69,-53.98,;35.52,-56.52,;28.19,-58.9,;26.73,-59.37,;28.51,-57.39,;27.37,-56.36,;25.9,-56.84,;24.76,-55.81,;25.58,-58.34,;27.69,-54.86,;29.15,-54.38,;26.54,-53.83,;26.87,-52.32,;28.33,-51.84,;28.65,-50.34,;30.11,-49.86,;30.43,-48.35,;31.26,-50.89,;25.72,-51.29,;24.26,-51.76,;26.04,-49.78,;24.9,-48.75,;23.43,-49.23,;22.29,-48.2,;20.82,-48.67,;19.68,-47.64,;20.5,-50.18,;25.22,-47.25,;26.68,-46.77,;24.07,-46.21,;24.39,-44.71,;25.86,-44.23,;26.18,-42.73,;27.64,-42.25,;27.96,-40.74,;29.43,-40.27,;29.75,-38.76,;30.57,-41.3,;23.25,-43.68,;21.78,-44.15,;23.57,-42.17,;22.42,-41.14,;20.96,-41.62,;19.81,-40.59,;18.35,-41.06,;17.21,-40.03,;15.74,-40.51,;22.74,-39.63,;24.21,-39.16,;21.6,-38.6,;21.92,-37.1,;23.38,-36.62,;23.7,-35.12,;25.17,-34.64,;25.49,-33.13,;26.31,-35.67,;20.77,-36.07,;19.31,-36.54,;21.1,-34.56,;19.95,-33.53,;18.49,-34.01,;17.34,-32.98,;20.27,-32.02,;21.74,-31.55,;19.13,-30.99,;19.45,-29.49,;20.91,-29.01,;21.23,-27.5,;22.7,-27.03,;23.02,-25.52,;24.48,-25.05,;18.3,-28.46,;16.84,-28.93,;18.62,-26.95,;17.48,-25.92,;16.01,-26.4,;14.87,-25.37,;13.4,-25.84,;12.26,-24.81,;10.79,-25.29,;17.8,-24.41,;19.26,-23.94,;16.65,-23.38,;15.15,-23.7,;14.38,-22.37,;15.41,-21.22,;16.81,-21.85,;18.15,-21.08,;19.48,-21.85,;18.15,-19.54,;16.9,-18.64,;17.38,-17.17,;18.92,-17.17,;19.39,-18.64,;20.86,-19.11,;21.18,-20.62,;22,-18.08,;21.68,-16.57,;20.22,-16.1,;22.83,-15.54,;24.29,-16.02,;22.51,-14.04,;23.65,-13.01,;25.12,-13.48,;26.26,-12.45,;27.73,-12.93,;28.87,-11.9,;30.33,-12.37,;23.33,-11.5,;21.87,-11.03,;24.48,-10.47,;24.16,-8.96,;22.69,-8.49,;21.66,-7.34,;20.15,-7.66,;22.14,-5.88,;25.3,-7.93,;26.76,-8.41,;24.98,-6.43,;26.12,-5.4,;27.59,-5.87,;28.73,-4.84,;30.2,-5.32,;30.52,-6.82,;31.34,-4.29,;25.8,-3.89,;24.34,-3.41,;26.95,-2.86,;28.46,-3.18,;29.23,-1.85,;28.19,-.7,;26.79,-1.33,;25.45,-.56,;24.12,-1.33,;25.45,.98,;26.79,1.75,;28.12,.98,;29.46,1.75,;30.79,.98,;32.12,1.75,;33.46,.98,;34.79,1.75,;33.46,-.56,;26.79,3.29,;28.12,4.06,;25.45,4.06,)| Show InChI InChI=1S/C149H249N47O42/c1-9-10-11-12-16-45-118(209)238-78-106(191-135(225)103(75-197)171-115(204)73-154)137(227)187-101(71-84-32-14-13-15-33-84)133(223)186-100(70-81(4)5)132(222)190-105(77-199)144(234)194-66-29-42-108(194)139(229)180-95(51-57-117(207)208)128(218)188-102(72-85-74-165-79-169-85)134(224)179-92(47-53-112(156)201)126(216)175-90(39-26-63-167-148(161)162)130(220)192-119(82(6)7)141(231)181-93(48-54-113(157)202)127(217)177-91(46-52-111(155)200)125(215)174-89(38-25-62-166-147(159)160)122(212)173-87(35-18-22-59-151)121(211)178-94(50-56-116(205)206)129(219)189-104(76-198)136(226)176-88(36-19-23-60-152)123(213)182-96(37-20-24-61-153)142(232)196-68-31-44-110(196)145(235)195-67-30-41-107(195)138(228)170-83(8)120(210)172-86(34-17-21-58-150)124(214)185-99(69-80(2)3)131(221)183-97(49-55-114(158)203)143(233)193-65-28-43-109(193)140(230)184-98(146(236)237)40-27-64-168-149(163)164/h13-15,32-33,74,79-83,86-110,119,197-199H,9-12,16-31,34-73,75-78,150-154H2,1-8H3,(H2,155,200)(H2,156,201)(H2,157,202)(H2,158,203)(H,165,169)(H,170,228)(H,171,204)(H,172,210)(H,173,212)(H,174,215)(H,175,216)(H,176,226)(H,177,217)(H,178,211)(H,179,224)(H,180,229)(H,181,231)(H,182,213)(H,183,221)(H,184,230)(H,185,214)(H,186,223)(H,187,227)(H,188,218)(H,189,219)(H,190,222)(H,191,225)(H,192,220)(H,205,206)(H,207,208)(H,236,237)(H4,159,160,166)(H4,161,162,167)(H4,163,164,168)/t83-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,119-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.40 | n/a | n/a | 7.2 | 22 |
Bristol-Myers Squibb Pharmaceutical Research Institute
| Assay Description
The functional FLIPR assay was developed from H4 glioma cells in which expression of the endogenous human GHS receptor was enhanced by RAGE-activatio... |
J Med Chem 50: 5890-3 (2007)
Article DOI: 10.1021/jm7010595
BindingDB Entry DOI: 10.7270/Q24J0CCV |
More data for this
Ligand-Target Pair | |
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