BDBM221043 US9284322, Table 6, Compound 9
SMILES: Nc1cc(ccn1)-c1cc(cnc1F)C1CC2CCC1N2
InChI Key: InChIKey=ZALPTLPCTBOPDH-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
nAChR alpha4 beta2 subtype (Rattus norvegicus (Rat)) | BDBM221043 (US9284322, Table 6, Compound 9) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.130 | -13.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Research Triangle Institute US Patent | Assay Description Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ... | US Patent US9284322 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor (Rattus norvegicus (Rat)) | BDBM221043 (US9284322, Table 6, Compound 9) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 719 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Research Triangle Institute US Patent | Assay Description Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay... | US Patent US9284322 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KCV | |||||||||||
More data for this Ligand-Target Pair |