BDBM22105 7-{[3-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one::Azetidine based compound, 35

SMILES: OCC1CN(Cc2c[nH]c3c2nc[nH]c3=O)C1

InChI Key: InChIKey=FADVRXOASKIWLY-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 22105   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Purine Nucleoside Phosphorylase (PNP) (Bos taurus (bovine))	BDBM22105 (7-{[3-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5...) Show SMILES OCC1CN(Cc2c[nH]c3c2nc[nH]c3=O)C1 Show InChI InChI=1S/C11H14N4O2/c16-5-7-2-15(3-7)4-8-1-12-10-9(8)13-6-14-11(10)17/h1,6-7,12,16H,2-5H2,(H,13,14,17)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	4.80	-11.2	n/a	n/a	n/a	n/a	n/a	7.7	22
Industrial Research Limited					Assay Description PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...				J Med Chem 51: 948-56 (2008) Article DOI: 10.1021/jm701265n BindingDB Entry DOI: 10.7270/Q2QC01T3
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM22105 (7-{[3-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5...) Show SMILES OCC1CN(Cc2c[nH]c3c2nc[nH]c3=O)C1 Show InChI InChI=1S/C11H14N4O2/c16-5-7-2-15(3-7)4-8-1-12-10-9(8)13-6-14-11(10)17/h1,6-7,12,16H,2-5H2,(H,13,14,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	6.30	-11.1	n/a	n/a	n/a	n/a	n/a	7.7	22
Industrial Research Limited					Assay Description PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...				J Med Chem 51: 948-56 (2008) Article DOI: 10.1021/jm701265n BindingDB Entry DOI: 10.7270/Q2QC01T3
					More data for this Ligand-Target Pair
Purine Nucleoside Phosphorylase (PNP) (Plasmodium falciparum)	BDBM22105 (7-{[3-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5...) Show SMILES OCC1CN(Cc2c[nH]c3c2nc[nH]c3=O)C1 Show InChI InChI=1S/C11H14N4O2/c16-5-7-2-15(3-7)4-8-1-12-10-9(8)13-6-14-11(10)17/h1,6-7,12,16H,2-5H2,(H,13,14,17)	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	>-6.75	n/a	n/a	n/a	n/a	n/a	7.7	22
Industrial Research Limited					Assay Description PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...				J Med Chem 51: 948-56 (2008) Article DOI: 10.1021/jm701265n BindingDB Entry DOI: 10.7270/Q2QC01T3
					More data for this Ligand-Target Pair