BDBM22116 aza-peptide Michael acceptor, 7b::benzyl (2E)-3-{N'-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}propanamido]propanoyl]-N-(carbamoylmethyl)hydrazinecarbonyl}prop-2-enoate
SMILES: C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)NN(CC(N)=O)C(=O)C=CC(=O)OCc1ccccc1
InChI Key: InChIKey=LAOGMMDQFBFYCI-OALUTQOASA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Asparaginyl Endopeptidase (AE) (Schistosoma mansoni) | BDBM22116 (aza-peptide Michael acceptor, 7b | benzyl (2E)-3-{...) | UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Georgia Institute of Technology | Assay Description AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors... | J Med Chem 51: 2816-32 (2008) Article DOI: 10.1021/jm701311r BindingDB Entry DOI: 10.7270/Q2KK9937 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Asparaginyl Endopeptidase (AE) (Ixodes ricinus) | BDBM22116 (aza-peptide Michael acceptor, 7b | benzyl (2E)-3-{...) | UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | 25 |
Georgia Institute of Technology | Assay Description AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors... | J Med Chem 51: 2816-32 (2008) Article DOI: 10.1021/jm701311r BindingDB Entry DOI: 10.7270/Q2KK9937 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Asparaginyl Endopeptidase (AE) (Trichomonas vaginalis G3) | BDBM22116 (aza-peptide Michael acceptor, 7b | benzyl (2E)-3-{...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Georgia Institute of Technology | Assay Description AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors... | J Med Chem 51: 2816-32 (2008) Article DOI: 10.1021/jm701311r BindingDB Entry DOI: 10.7270/Q2KK9937 | |||||||||||
More data for this Ligand-Target Pair |