BDBM22153 (3R,5S,6E)-7-{2-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)amino]-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid::pyrazole compound, 11a
SMILES: CC(C)c1nc(Nc2cc(nn2C)C(C)(C)C)nc(-c2ccc(F)cc2)c1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O
InChI Key: InChIKey=OHTJDABXTNGMCT-XICOBVEKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HMG-CoA reductase (Rattus norvegicus (rat)) | BDBM22153 ((3R,5S,6E)-7-{2-[(3-tert-butyl-1-methyl-1H-pyrazol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 12.4 | n/a | 1.90 | n/a | n/a | 7.0 | 37 |
Bristol-Myers Squibb Company | Assay Description Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme... | J Med Chem 51: 2722-33 (2008) Article DOI: 10.1021/jm800001n BindingDB Entry DOI: 10.7270/Q2FT8JB2 | |||||||||||
More data for this Ligand-Target Pair |