BDBM221942 US9303035, 1.10

SMILES: CCc1ccc(o1)C1NCCn2c1c1n(C)c(=O)n(C)c(=O)c1c2-c1ccccc1

InChI Key: InChIKey=PIDQOBZLBVMWFL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221942   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cystic fibrosis transmembrane conductance regulator protein (CFTR) (Cricetulus griseus (Chinese hamster))	BDBM221942 (US9303035, 1.10) Show SMILES CCc1ccc(o1)C1NCCn2c1c1n(C)c(=O)n(C)c(=O)c1c2-c1ccccc1 Show InChI InChI=1S/C23H24N4O3/c1-4-15-10-11-16(30-15)18-21-20-17(22(28)26(3)23(29)25(20)2)19(27(21)13-12-24-18)14-8-6-5-7-9-14/h5-11,18,24H,4,12-13H2,1-3H3	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.37	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...				US Patent US9303035 (2016) BindingDB Entry DOI: 10.7270/Q2SQ8Z7R
					More data for this Ligand-Target Pair