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BDBM221967 US9303035, 2.9

SMILES: Cn1c2c3C(NCCn3c(-c3cccc(c3)C#N)c2c(=O)n(C)c1=O)c1ccc(Cl)o1

InChI Key: InChIKey=IQOHEKUCKAGGKV-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221967   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cystic fibrosis transmembrane conductance regulator protein (CFTR)


(Cricetulus griseus (Chinese hamster))
BDBM221967
PNG
(US9303035, 2.9)
Show SMILES Cn1c2c3C(NCCn3c(-c3cccc(c3)C#N)c2c(=O)n(C)c1=O)c1ccc(Cl)o1
Show InChI InChI=1/C22H18ClN5O3/c1-26-19-16(21(29)27(2)22(26)30)18(13-5-3-4-12(10-13)11-24)28-9-8-25-17(20(19)28)14-6-7-15(23)31-14/h3-7,10,17,25H,8-9H2,1-2H3
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.590n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...


Citation and Details
More data for this
Ligand-Target Pair