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SMILES: Cn1c2c3[C@H](O[C@H](CO)Cn3c(-c3cccc(c3)C#N)c2c(=O)n(C)c1=O)c1nc(Cl)cs1

InChI Key: InChIKey=GMANXRNKIWGMRW-DJJJIMSYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221979   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cystic fibrosis transmembrane conductance regulator


(Cricetulus griseus (Chinese hamster))		BDBM221979
PNG
(US9303035, 4.2)
Show SMILES Cn1c2c3[C@H](O[C@H](CO)Cn3c(-c3cccc(c3)C#N)c2c(=O)n(C)c1=O)c1nc(Cl)cs1 |r|
Show InChI InChI=1S/C22H18ClN5O4S/c1-26-17-15(21(30)27(2)22(26)31)16(12-5-3-4-11(6-12)7-24)28-8-13(9-29)32-19(18(17)28)20-25-14(23)10-33-20/h3-6,10,13,19,29H,8-9H2,1-2H3/t13-,19-/m0/s1
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
US Patent
n/an/a>30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...

US Patent US9303035 (2016)


BindingDB Entry DOI: 10.7270/Q2SQ8Z7R
More data for this
Ligand-Target Pair