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SMILES: Cn1c2c3[C@@H](O[C@@H](CO)Cn3c(-c3cccc(F)c3)c2c(=O)n(C)c1=O)c1ccc(Cl)o1

InChI Key: InChIKey=QWVLUGULIQRNTG-XCLFUZPHSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221982   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cystic fibrosis transmembrane conductance regulator


(Cricetulus griseus (Chinese hamster))		BDBM221982
PNG
(US9303035, 6)
Show SMILES Cn1c2c3[C@@H](O[C@@H](CO)Cn3c(-c3cccc(F)c3)c2c(=O)n(C)c1=O)c1ccc(Cl)o1
Show InChI InChI=1S/C22H19ClFN3O5/c1-25-18-16(21(29)26(2)22(25)30)17(11-4-3-5-12(24)8-11)27-9-13(10-28)31-20(19(18)27)14-6-7-15(23)32-14/h3-8,13,20,28H,9-10H2,1-2H3/t13-,20+/m1/s1
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...

US Patent US9303035 (2016)


BindingDB Entry DOI: 10.7270/Q2SQ8Z7R
More data for this
Ligand-Target Pair