BindingDB logo
myBDB logout

null

SMILES: CN(C)CC1Cn2c(C(O1)c1ccc(Cl)o1)c1n(C)c(=O)n(C)c(=O)c1c2-c1cccc(Cl)c1

InChI Key: InChIKey=YDKMUVNWFCEBFB-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221993   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cystic fibrosis transmembrane conductance regulator


(Cricetulus griseus (Chinese hamster))		BDBM221993
PNG
(US9303035, 12.4)
Show SMILES CN(C)CC1Cn2c(C(O1)c1ccc(Cl)o1)c1n(C)c(=O)n(C)c(=O)c1c2-c1cccc(Cl)c1
Show InChI InChI=1S/C24H24Cl2N4O4/c1-27(2)11-15-12-30-19(13-6-5-7-14(25)10-13)18-20(28(3)24(32)29(4)23(18)31)21(30)22(33-15)16-8-9-17(26)34-16/h5-10,15,22H,11-12H2,1-4H3
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.540n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...

US Patent US9303035 (2016)


BindingDB Entry DOI: 10.7270/Q2SQ8Z7R
More data for this
Ligand-Target Pair