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SMILES: Cn1c2c3C(COCCn3c(-c3ccccc3)c2c(=O)n(C)c1=O)c1nc(Cl)cs1

InChI Key: InChIKey=OLAXJBSLWIKVCB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221995   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cystic fibrosis transmembrane conductance regulator


(Cricetulus griseus (Chinese hamster))		BDBM221995
PNG
(US9303035, 13)
Show SMILES Cn1c2c3C(COCCn3c(-c3ccccc3)c2c(=O)n(C)c1=O)c1nc(Cl)cs1
Show InChI InChI=1S/C21H19ClN4O3S/c1-24-18-15(20(27)25(2)21(24)28)16(12-6-4-3-5-7-12)26-8-9-29-10-13(17(18)26)19-23-14(22)11-30-19/h3-7,11,13H,8-10H2,1-2H3
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.53n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...

US Patent US9303035 (2016)


BindingDB Entry DOI: 10.7270/Q2SQ8Z7R
More data for this
Ligand-Target Pair