BDBM222078 6-Chloro-3-((2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridin-8-yl)methoxy)-[1,2,4]triazolo[4,3-b] pyridazine (7g)

SMILES: Clc1ccc(-c2cn3cccc(COc4nnc5ccc(Cl)nn45)c3n2)c(Cl)c1

InChI Key: InChIKey=QJQFWXRUJUNRHW-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 222078   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
c-Met/EGFR (Homo sapiens (Human))	BDBM222078 (6-Chloro-3-((2-(2,4-dichlorophenyl)imidazo[1,2-a]p...) Show SMILES Clc1ccc(-c2cn3cccc(COc4nnc5ccc(Cl)nn45)c3n2)c(Cl)c1 Show InChI InChI=1S/C19H11Cl3N6O/c20-12-3-4-13(14(21)8-12)15-9-27-7-1-2-11(18(27)23-15)10-29-19-25-24-17-6-5-16(22)26-28(17)19/h1-9H,10H2	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University					Assay Description The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...				Bioorg Chem 70: 126-132 (2017) Article DOI: 10.1016/j.bioorg.2016.12.002 BindingDB Entry DOI: 10.7270/Q23X85HP
					More data for this Ligand-Target Pair
c-Met/RET (Homo sapiens (Human))	BDBM222078 (6-Chloro-3-((2-(2,4-dichlorophenyl)imidazo[1,2-a]p...) Show SMILES Clc1ccc(-c2cn3cccc(COc4nnc5ccc(Cl)nn45)c3n2)c(Cl)c1 Show InChI InChI=1S/C19H11Cl3N6O/c20-12-3-4-13(14(21)8-12)15-9-27-7-1-2-11(18(27)23-15)10-29-19-25-24-17-6-5-16(22)26-28(17)19/h1-9H,10H2	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.22E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University					Assay Description The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...				Bioorg Chem 70: 126-132 (2017) Article DOI: 10.1016/j.bioorg.2016.12.002 BindingDB Entry DOI: 10.7270/Q23X85HP
					More data for this Ligand-Target Pair
c-Met/ALK (Homo sapiens (Human))	BDBM222078 (6-Chloro-3-((2-(2,4-dichlorophenyl)imidazo[1,2-a]p...) Show SMILES Clc1ccc(-c2cn3cccc(COc4nnc5ccc(Cl)nn45)c3n2)c(Cl)c1 Show InChI InChI=1S/C19H11Cl3N6O/c20-12-3-4-13(14(21)8-12)15-9-27-7-1-2-11(18(27)23-15)10-29-19-25-24-17-6-5-16(22)26-28(17)19/h1-9H,10H2	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University					Assay Description The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...				Bioorg Chem 70: 126-132 (2017) Article DOI: 10.1016/j.bioorg.2016.12.002 BindingDB Entry DOI: 10.7270/Q23X85HP
					More data for this Ligand-Target Pair