BDBM222182 6-(Dimethylamino)-3-(4'-hydroxyphenyl)-2,3-dihydronaphtho[1,8-de][1,2]thiazine 1,1-dioxide (7d)

SMILES: CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1ccc(O)cc1

InChI Key: InChIKey=RAHOWKGDVTTXED-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 222182   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tissue non-specific alkaline phosphatase (TNAP) (Bos taurus (Cattle))	BDBM222182 (6-(Dimethylamino)-3-(4'-hydroxyphenyl)-2,3-dih...) Show SMILES CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1ccc(O)cc1 Show InChI InChI=1S/C19H18N2O3S/c1-21(2)16-11-10-15-18-14(16)4-3-5-17(18)25(23,24)20-19(15)12-6-8-13(22)9-7-12/h3-11,19-20,22H,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	9.8	37
University of Karachi					Assay Description Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...				Bioorg Chem 71: 10-18 (2017) Article DOI: 10.1016/j.bioorg.2017.01.008 BindingDB Entry DOI: 10.7270/Q26Q1W36
					More data for this Ligand-Target Pair