BDBM222187 6-(Dimethylamino)-3-(2'-methoxyphenyl)-2,3-dihydronaphtho[1,8-de][1,2]thiazine 1,1-dioxide (7i)

SMILES: COc1ccccc1C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C

InChI Key: InChIKey=XCFDDEOGVFLXBA-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 222187   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tissue non-specific alkaline phosphatase (TNAP) (Bos taurus (Cattle))	BDBM222187 (6-(Dimethylamino)-3-(2'-methoxyphenyl)-2,3-dih...) Show SMILES COc1ccccc1C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C Show InChI InChI=1S/C20H20N2O3S/c1-22(2)16-12-11-15-19-13(16)8-6-10-18(19)26(23,24)21-20(15)14-7-4-5-9-17(14)25-3/h4-12,20-21H,1-3H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	9.8	37
University of Karachi					Assay Description Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...				Bioorg Chem 71: 10-18 (2017) Article DOI: 10.1016/j.bioorg.2017.01.008 BindingDB Entry DOI: 10.7270/Q26Q1W36
					More data for this Ligand-Target Pair