BDBM222192 6-(Dimethylamino)-3-(2',3',4'-trimethoxyphenyl)-2,3-dihydronaphtho[1,8-de][1,2]thiazine 1,1-dioxide (7n)

SMILES: COc1ccc(C2NS(=O)(=O)c3cccc4c(ccc2c34)N(C)C)c(OC)c1OC

InChI Key: InChIKey=CMULYEZYDUFFOB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 222192   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alkaline phosphatase, tissue-nonspecific isozyme (Bos taurus (Cattle))	BDBM222192 (6-(Dimethylamino)-3-(2',3',4'-trimetho...) Show SMILES COc1ccc(C2NS(=O)(=O)c3cccc4c(ccc2c34)N(C)C)c(OC)c1OC Show InChI InChI=1S/C22H24N2O5S/c1-24(2)16-11-9-14-19-13(16)7-6-8-18(19)30(25,26)23-20(14)15-10-12-17(27-3)22(29-5)21(15)28-4/h6-12,20,23H,1-5H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	9.8	37
University of Karachi					Assay Description Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...				Bioorg Chem 71: 10-18 (2017) Article DOI: 10.1016/j.bioorg.2017.01.008 BindingDB Entry DOI: 10.7270/Q26Q1W36
					More data for this Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme (Bos taurus (Cattle))	BDBM222192 (6-(Dimethylamino)-3-(2',3',4'-trimetho...) Show SMILES COc1ccc(C2NS(=O)(=O)c3cccc4c(ccc2c34)N(C)C)c(OC)c1OC Show InChI InChI=1S/C22H24N2O5S/c1-24(2)16-11-9-14-19-13(16)7-6-8-18(19)30(25,26)23-20(14)15-10-12-17(27-3)22(29-5)21(15)28-4/h6-12,20,23H,1-5H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.19E+3	n/a	n/a	n/a	n/a	9.8	37
University of Karachi					Assay Description Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...				Bioorg Chem 71: 10-18 (2017) Article DOI: 10.1016/j.bioorg.2017.01.008 BindingDB Entry DOI: 10.7270/Q26Q1W36
					More data for this Ligand-Target Pair