BDBM2222 2-Pyridinone derivative 20::3-[2-(4,7-dimethyl-1,3-benzoxazol-2-yl)ethyl]-5-ethyl-6-methyl-1,2-dihydropyridin-2-one::CHEMBL329720::Pyridinone deriv. 15
SMILES: CCc1cc(CCc2nc3c(C)ccc(C)c3o2)c(=O)[nH]c1C
InChI Key: InChIKey=XKSPCHATHZHOGY-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM2222 (2-Pyridinone derivative 20 | 3-[2-(4,7-dimethyl-1,...) | PDB MMDB B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Sharp and Dohme Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1) | BDBM2222 (2-Pyridinone derivative 20 | 3-[2-(4,7-dimethyl-1,...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Reserch Laboratories Curated by ChEMBL | Assay Description Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template) | J Med Chem 36: 953-66 (1993) BindingDB Entry DOI: 10.7270/Q2JW8G28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM2222 (2-Pyridinone derivative 20 | 3-[2-(4,7-dimethyl-1,...) | PDB MMDB B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Reserch Laboratories Curated by ChEMBL | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 36: 953-66 (1993) BindingDB Entry DOI: 10.7270/Q2JW8G28 | |||||||||||
More data for this Ligand-Target Pair |