BindingDB PrimarySearch

BDBM22231 (9Z,12Z)-octadeca-9,12-dienoic acid::CHEMBL267476::Linoleic Acid::Linoleic acid (LA)

SMILES: CCCCC\C=C/C\C=C/CCCCCCCC(O)=O

InChI Key: InChIKey=OYHQOLUKZRVURQ-HZJYTTRNSA-N

Data: 5 KI 25 IC50 1 Kd 6 EC50

PDB links: 19 PDB IDs match this monomer. 4 PDB IDs contain this monomer as substructures. 4 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 22231
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fatty acid-binding protein 5 (FABP5) (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.26E+3	-8.18	n/a	n/a	n/a	n/a	n/a	8.2	30
Emory University School of Medicine					Assay Description In brief, both wild-type and mutant hFABP5 were expressed and purified to homogeneity as described above and dialyzed in PBS (pH 8.2). Binding affini...				J Biol Chem 289: 14941-54 (2014) Article DOI: 10.1074/jbc.M113.514646 BindingDB Entry DOI: 10.7270/Q21835CT
Emory University School of Medicine					More data for this Ligand-Target Pair				3D Structure (crystal)
Fatty acid-binding protein 5 (FABP5)(NLSm) (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	2.17E+3	-7.85	n/a	n/a	n/a	n/a	n/a	8.2	30
Emory University School of Medicine					Assay Description In brief, both wild-type and mutant hFABP5 were expressed and purified to homogeneity as described above and dialyzed in PBS (pH 8.2). Binding affini...				J Biol Chem 289: 14941-54 (2014) Article DOI: 10.1074/jbc.M113.514646 BindingDB Entry DOI: 10.7270/Q21835CT
Emory University School of Medicine					More data for this Ligand-Target Pair				3D Structure (crystal)
Fatty acid-binding protein 5 (FABP5)(DSm) (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	3.47E+3	-7.57	n/a	n/a	n/a	n/a	n/a	8.2	30
Emory University School of Medicine					Assay Description In brief, both wild-type and mutant hFABP5 were expressed and purified to homogeneity as described above and dialyzed in PBS (pH 8.2). Binding affini...				J Biol Chem 289: 14941-54 (2014) Article DOI: 10.1074/jbc.M113.514646 BindingDB Entry DOI: 10.7270/Q21835CT
Emory University School of Medicine					More data for this Ligand-Target Pair				3D Structure (crystal)
Fatty acid-binding protein 4 (FABP4) (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assay				Bioorg Med Chem 24: 4310-4317 (2016) BindingDB Entry DOI: 10.7270/Q2NC634M
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Fatty acid binding protein muscle (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Displacement of 1,8-ANS from His6-tagged FABP3 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assay				Bioorg Med Chem 24: 4310-4317 (2016) BindingDB Entry DOI: 10.7270/Q2NC634M
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 4 (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	Reactome pathway KEGG GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	316	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR				Bioorg Med Chem Lett 24: 3100-3 (2014) Article DOI: 10.1016/j.bmcl.2014.05.012 BindingDB Entry DOI: 10.7270/Q2CC1292
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid binding protein muscle (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of FABP4 (unknown origin) relative to linoleic acid				Eur J Med Chem 90: 241-50 (2015) Article DOI: 10.1016/j.ejmech.2014.11.020 BindingDB Entry DOI: 10.7270/Q29K4CXF
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid binding protein muscle (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of FABP3 (unknown origin) relative to linoleic acid				Eur J Med Chem 90: 241-50 (2015) Article DOI: 10.1016/j.ejmech.2014.11.020 BindingDB Entry DOI: 10.7270/Q29K4CXF
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4) (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.77E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of FABP4 (unknown origin)				Eur J Med Chem 90: 241-50 (2015) Article DOI: 10.1016/j.ejmech.2014.11.020 BindingDB Entry DOI: 10.7270/Q29K4CXF
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 19A1 (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of aromatase in human placental microsomes by radiometric method				J Nat Prod 69: 700-3 (2006) Article DOI: 10.1021/np050513p BindingDB Entry DOI: 10.7270/Q2J96647
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	540	n/a	n/a	n/a	n/a
Piramal Life Sciences Limited Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay				Bioorg Med Chem Lett 18: 6357-61 (2008) Article DOI: 10.1016/j.bmcl.2008.10.085 BindingDB Entry DOI: 10.7270/Q2FT8KWN
Piramal Life Sciences Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	540	n/a	n/a	n/a	n/a
Piramal Life Sciences Limited Curated by ChEMBL					Assay Description Agonist activity at GPR40 (unknown origin)				Bioorg Med Chem Lett 18: 6357-61 (2008) Article DOI: 10.1016/j.bmcl.2008.10.085 BindingDB Entry DOI: 10.7270/Q2FT8KWN
Piramal Life Sciences Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a
Piramal Life Sciences Limited Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem Lett 18: 6357-61 (2008) Article DOI: 10.1016/j.bmcl.2008.10.085 BindingDB Entry DOI: 10.7270/Q2FT8KWN
Piramal Life Sciences Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a
East China Normal University Curated by ChEMBL					Assay Description Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay				Bioorg Med Chem Lett 29: 848-852 (2019) Article DOI: 10.1016/j.bmcl.2019.01.014
East China Normal University Curated by ChEMBL					More data for this Ligand-Target Pair
Lipoxygenase-1 (Glycine max (soybean))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Mixed-type inhibition of soybean LO1				Bioorg Med Chem 17: 6534-9 (2009) Article DOI: 10.1016/j.bmc.2009.08.005 BindingDB Entry DOI: 10.7270/Q2SQ90GP
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Lipoxygenase-1 (Glycine max (soybean))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Allosteric inhibition of soybean LO1				Bioorg Med Chem 17: 6534-9 (2009) Article DOI: 10.1016/j.bmc.2009.08.005 BindingDB Entry DOI: 10.7270/Q2SQ90GP
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4) (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 mins				Bioorg Med Chem Lett 20: 3675-9 (2010) Article DOI: 10.1016/j.bmcl.2010.04.095 BindingDB Entry DOI: 10.7270/Q2CV4HXG
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Fatty acid binding protein muscle (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP3 expressed in Escherichia coli BL21 (DE3) cells after 3 mins relative to li...				Bioorg Med Chem Lett 20: 3675-9 (2010) Article DOI: 10.1016/j.bmcl.2010.04.095 BindingDB Entry DOI: 10.7270/Q2CV4HXG
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid-binding protein 4 (FABP4) (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 mins relative to li...				Bioorg Med Chem Lett 20: 3675-9 (2010) Article DOI: 10.1016/j.bmcl.2010.04.095 BindingDB Entry DOI: 10.7270/Q2CV4HXG
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity protein phosphatase (VHR) (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Xiamen University Curated by ChEMBL					Assay Description Inhibition of GST-tagged human VHR using pNpp as substrate after 30 mins				Bioorg Med Chem Lett 21: 6833-7 (2011) Article DOI: 10.1016/j.bmcl.2011.09.023 BindingDB Entry DOI: 10.7270/Q2CJ8DW6
Xiamen University Curated by ChEMBL					More data for this Ligand-Target Pair
Hematopoietic protein-tyrosine phosphatase (HEPTP) (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Xiamen University Curated by ChEMBL					Assay Description Inhibition of GST-tagged human HePTP using pNpp as substrate after 30 mins				Bioorg Med Chem Lett 21: 6833-7 (2011) Article DOI: 10.1016/j.bmcl.2011.09.023 BindingDB Entry DOI: 10.7270/Q2CJ8DW6
Xiamen University Curated by ChEMBL					More data for this Ligand-Target Pair
Sterol O-acyltransferase, Soat (Rattus norvegicus)	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Bioscience and Biotechnology Curated by ChEMBL					Assay Description Inhibitory activity against rat liver microsomal Acyl coenzyme A:cholesterol acyltransferase				Bioorg Med Chem Lett 14: 4277-80 (2004) Article DOI: 10.1016/j.bmcl.2004.05.086 BindingDB Entry DOI: 10.7270/Q261113Z
					More data for this Ligand-Target Pair
Sterol O-acyltransferase 1 (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Bioscience and Biotechnology Curated by ChEMBL					Assay Description Inhibitory activity against human Acyl coenzyme A:cholesterol acyltransferase 2				Bioorg Med Chem Lett 14: 4277-80 (2004) Article DOI: 10.1016/j.bmcl.2004.05.086 BindingDB Entry DOI: 10.7270/Q261113Z
					More data for this Ligand-Target Pair
Sterol O-acyltransferase 1 (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Bioscience and Biotechnology Curated by ChEMBL					Assay Description Inhibitory activity against human Acyl coenzyme A:cholesterol acyltransferase 1				Bioorg Med Chem Lett 14: 4277-80 (2004) Article DOI: 10.1016/j.bmcl.2004.05.086 BindingDB Entry DOI: 10.7270/Q261113Z
					More data for this Ligand-Target Pair
Cyclooxygenase-1 (COX-1) (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of COX1				J Nat Prod 68: 985-91 (2005) Article DOI: 10.1021/np049655u BindingDB Entry DOI: 10.7270/Q27S7PN5
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assa...				Bioorg Med Chem 26: 5780-5791 (2018) Article DOI: 10.1016/j.bmc.2018.10.019 BindingDB Entry DOI: 10.7270/Q2319ZKH
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scintillation proximity assay				Citation and Details Article DOI: 10.1007/s00044-012-0285-6 BindingDB Entry DOI: 10.7270/Q2MG7SDK
TBA					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assay				Citation and Details Article DOI: 10.1007/s00044-012-0285-6 BindingDB Entry DOI: 10.7270/Q2MG7SDK
TBA					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assay				Citation and Details Article DOI: 10.1007/s00044-012-0285-6 BindingDB Entry DOI: 10.7270/Q2MG7SDK
TBA					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to PPAR-alpha (unknown origin) by fluorescence-based assay				Citation and Details Article DOI: 10.1007/s00044-008-9102-7 BindingDB Entry DOI: 10.7270/Q2K35XJ5
TBA					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PPAR-alpha (unknown origin) by SPA assay				Citation and Details Article DOI: 10.1007/s00044-008-9102-7 BindingDB Entry DOI: 10.7270/Q2K35XJ5
TBA					More data for this Ligand-Target Pair
Cyclooxygenase (Bos taurus)	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	1.70E+5	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of bovine COX1-mediated prostaglandin biosynthesis using [1-14C]arachidonic acid				J Nat Prod 64: 745-9 (2001) BindingDB Entry DOI: 10.7270/Q24J0DVJ
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin G/H synthase (Cyclooxygenase-2) (Ovis aries (Sheep))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	9.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of sheep COX2-mediated prostaglandin biosynthesis using [1-14C]arachidonic acid				J Nat Prod 64: 745-9 (2001) BindingDB Entry DOI: 10.7270/Q24J0DVJ
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Adenosine receptor A1 (Rattus norvegicus (rat))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Displacement of [3H]DPCPX from rat adenosine A1 receptor by liquid scintillation counting				J Nat Prod 62: 912-4 (1999) Article DOI: 10.1021/np9805490 BindingDB Entry DOI: 10.7270/Q2W66KHS
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
Coagulation factor VII/tissue factor (Homo sapiens (Human))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Searle Discovery Research Curated by ChEMBL					Assay Description Inhibition of amidolytic activity of human tissue factor/human factor 7a				J Nat Prod 61: 1352-5 (1999) Article DOI: 10.1021/np980117p BindingDB Entry DOI: 10.7270/Q2SF2VXF
Searle Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Trypsin (Sus scrofa)	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Searle Discovery Research Curated by ChEMBL					Assay Description Inhibition of pig pancreatic trypsin after 15 mins				J Nat Prod 61: 1352-5 (1999) Article DOI: 10.1021/np980117p BindingDB Entry DOI: 10.7270/Q2SF2VXF
Searle Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Lipoxygenase-1 (Glycine max (soybean))	BDBM22231 ((9Z,12Z)-octadeca-9,12-dienoic acid \| CHEMBL267476...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Competitive inhibition of soybean LO1				Bioorg Med Chem 17: 6534-9 (2009) Article DOI: 10.1016/j.bmc.2009.08.005 BindingDB Entry DOI: 10.7270/Q2SQ90GP
University of California Curated by ChEMBL					More data for this Ligand-Target Pair