BDBM2224 2-Pyridinone derivative 4::3-(2-Phenylethyl)-5-ethyl-6-methylpyridin-2(1H)-one::5-ethyl-6-methyl-3-(2-phenylethyl)-1,2-dihydropyridin-2-one::CHEMBL353328
SMILES: CCc1cc(CCc2ccccc2)c(=O)[nH]c1C
InChI Key: InChIKey=RWEXZYPUDQKVSX-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1) | BDBM2224 (2-Pyridinone derivative 4 | 3-(2-Phenylethyl)-5-et...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Reserch Laboratories Curated by ChEMBL | Assay Description Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template) | J Med Chem 36: 953-66 (1993) BindingDB Entry DOI: 10.7270/Q2JW8G28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM2224 (2-Pyridinone derivative 4 | 3-(2-Phenylethyl)-5-et...) | PDB MMDB B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Reserch Laboratories Curated by ChEMBL | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 36: 953-66 (1993) BindingDB Entry DOI: 10.7270/Q2JW8G28 | |||||||||||
More data for this Ligand-Target Pair |