BDBM222967 US9315518, 2-8
SMILES: Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CCC1CN2C(=O)c1csnn1
InChI Key: InChIKey=YBEWYHYVINQVQI-UHFFFAOYSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM222967 (US9315518, 2-8) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 69.3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The stimulation of [35S]-GTPγS binding is a common functional assay to monitor Gαi-coupled receptor in native and recombinant receptor memb... | US Patent US9315518 (2016) BindingDB Entry DOI: 10.7270/Q2G44P5C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
mGluR2 and G alpha 16 (Homo sapiens (Human)) | BDBM222967 (US9315518, 2-8) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 28.1 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio... | US Patent US9315518 (2016) BindingDB Entry DOI: 10.7270/Q2G44P5C | |||||||||||
More data for this Ligand-Target Pair |