BDBM222970 US9315518, 2-22

SMILES: Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CCC1CN2C(=O)Cn1cncn1

InChI Key: InChIKey=WNILPHCEVJNPJL-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 222970   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM222970 (US9315518, 2-22) Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CCC1CN2C(=O)Cn1cncn1 |t:18| Show InChI InChI=1S/C23H29N7O2/c1-23(2,3)12-30-19-8-7-18(26-21(19)27(4)22(30)32)17-9-16-6-5-15(17)10-29(16)20(31)11-28-14-24-13-25-28/h7-9,13-16H,5-6,10-12H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	115	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The stimulation of [35S]-GTPγS binding is a common functional assay to monitor Gαi-coupled receptor in native and recombinant receptor memb...				US Patent US9315518 (2016) BindingDB Entry DOI: 10.7270/Q2G44P5C
					More data for this Ligand-Target Pair
mGluR2 and G alpha 16 (Homo sapiens (Human))	BDBM222970 (US9315518, 2-22) Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CCC1CN2C(=O)Cn1cncn1 |t:18| Show InChI InChI=1S/C23H29N7O2/c1-23(2,3)12-30-19-8-7-18(26-21(19)27(4)22(30)32)17-9-16-6-5-15(17)10-29(16)20(31)11-28-14-24-13-25-28/h7-9,13-16H,5-6,10-12H2,1-4H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	56.1	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The compounds of the present invention may be tested in a fluorescence laser imaging plate reader (FLIPR) based assay. This assay is a common functio...				US Patent US9315518 (2016) BindingDB Entry DOI: 10.7270/Q2G44P5C
					More data for this Ligand-Target Pair