BDBM223102 N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-((1-(methylsulfonyl)pyrrolidin-3-yl)amino)-pyrimidin-4-yl)amino)thiazole-5-carboxamide (5i)
SMILES: Cc1nc(NC2CCN(C2)S(C)(=O)=O)cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)n1
InChI Key: InChIKey=LTQIPTSOJUTHQH-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human)) | BDBM223102 (N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-((1-(me...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 11.7 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences | Assay Description The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad... | Chem Biol Drug Des 89: 420-427 (2017) Article DOI: 10.1111/cbdd.12863 BindingDB Entry DOI: 10.7270/Q29C6W98 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 (Homo sapiens (Human)) | BDBM223102 (N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-((1-(me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.293 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences | Assay Description ABL activity assays were performed in 384-well plate using the FRET-based Z'-Lyteassay system and Tyr-2 peptide substrate according to the manufa... | Chem Biol Drug Des 89: 420-427 (2017) Article DOI: 10.1111/cbdd.12863 BindingDB Entry DOI: 10.7270/Q29C6W98 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Discoidin domain-containing receptor 2 (Homo sapiens (Human)) | BDBM223102 (N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-((1-(me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 38.3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences | Assay Description The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad... | Chem Biol Drug Des 89: 420-427 (2017) Article DOI: 10.1111/cbdd.12863 BindingDB Entry DOI: 10.7270/Q29C6W98 | |||||||||||
More data for this Ligand-Target Pair |