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SMILES: Cc1ccc2NC(=O)\C(=N/NC(=O)COc3ccc4ccc(=O)oc4c3)c2c1

InChI Key: InChIKey=GWKSOXGHMJEYHY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 223107   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Probable maltase-glucoamylase 2


(Homo sapiens)
BDBM223107
PNG
((Z)-N'-(5-methyl-2-oxoindolin-3-ylidene)-2-((2...)
Show SMILES Cc1ccc2NC(=O)\C(=N/NC(=O)COc3ccc4ccc(=O)oc4c3)c2c1
Show InChI InChI=1S/C20H15N3O5/c1-11-2-6-15-14(8-11)19(20(26)21-15)23-22-17(24)10-27-13-5-3-12-4-7-18(25)28-16(12)9-13/h2-9H,10H2,1H3,(H,22,24)(H,21,23,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Babasaheb Bhimrao Ambedkar University (A Central University)

Curated by ChEMBL


Assay Description
Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl-alpha-d-glucopyranoside as substrate preincubated for 15 mins followed by substr...


Eur J Med Chem 176: 343-377 (2019)


Article DOI: 10.1016/j.ejmech.2019.04.025
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL32


(Saccharomyces cerevisiae)
BDBM223107
PNG
((Z)-N'-(5-methyl-2-oxoindolin-3-ylidene)-2-((2...)
Show SMILES Cc1ccc2NC(=O)\C(=N/NC(=O)COc3ccc4ccc(=O)oc4c3)c2c1
Show InChI InChI=1S/C20H15N3O5/c1-11-2-6-15-14(8-11)19(20(26)21-15)23-22-17(24)10-27-13-5-3-12-4-7-18(25)28-16(12)9-13/h2-9H,10H2,1H3,(H,22,24)(H,21,23,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.14E+5n/an/an/an/a6.8n/a



Jishou University



Assay Description
The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed usin...


Chem Biol Drug Des 89: 456-463 (2017)


Article DOI: 10.1111/cbdd.12867
BindingDB Entry DOI: 10.7270/Q25M64KX
More data for this
Ligand-Target Pair