BDBM223111 (Z)-N'-(5-bromo-2-oxoindolin-3-ylidene)-2-((2-oxo-2H-chromen-7-yl)oxy)acetohydrazide (5f)
SMILES: Brc1ccc2NC(=O)\C(=N/NC(=O)COc3ccc4ccc(=O)oc4c3)c2c1
InChI Key: InChIKey=JVADQIIOUOPWLP-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Probable maltase-glucoamylase 2 (Homo sapiens) | BDBM223111 ((Z)-N'-(5-bromo-2-oxoindolin-3-ylidene)-2-((2-...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Babasaheb Bhimrao Ambedkar University (A Central University) Curated by ChEMBL | Assay Description Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl-alpha-d-glucopyranoside as substrate preincubated for 15 mins followed by substr... | Eur J Med Chem 176: 343-377 (2019) Article DOI: 10.1016/j.ejmech.2019.04.025 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase MAL32 (Saccharomyces cerevisiae) | BDBM223111 ((Z)-N'-(5-bromo-2-oxoindolin-3-ylidene)-2-((2-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.42E+4 | n/a | n/a | n/a | n/a | 6.8 | n/a |
Jishou University | Assay Description The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed usin... | Chem Biol Drug Des 89: 456-463 (2017) Article DOI: 10.1111/cbdd.12867 BindingDB Entry DOI: 10.7270/Q25M64KX | |||||||||||
More data for this Ligand-Target Pair |