BDBM223114 (Z)-N'-(1-benzyl-2-oxoindolin-3-ylidene)-2-((2-oxo-2H-chromen-7-yl)oxy)acetohydrazide (5i)
SMILES: O=C(COc1ccc2ccc(=O)oc2c1)N\N=C1/C(=O)N(Cc2ccccc2)c2ccccc12
InChI Key: InChIKey=VNHLETGCKKZPSE-FVDSYPCUSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Probable maltase-glucoamylase 2 (Homo sapiens) | BDBM223114 ((Z)-N'-(1-benzyl-2-oxoindolin-3-ylidene)-2-((2...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Babasaheb Bhimrao Ambedkar University (A Central University) Curated by ChEMBL | Assay Description Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl-alpha-d-glucopyranoside as substrate preincubated for 15 mins followed by substr... | Eur J Med Chem 176: 343-377 (2019) Article DOI: 10.1016/j.ejmech.2019.04.025 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
alpha-Glucosidase (alpha-Glu) (Saccharomyces cerevisiae) | BDBM223114 ((Z)-N'-(1-benzyl-2-oxoindolin-3-ylidene)-2-((2...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.41E+4 | n/a | n/a | n/a | n/a | 6.8 | n/a |
Jishou University | Assay Description The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed usin... | Chem Biol Drug Des 89: 456-463 (2017) Article DOI: 10.1111/cbdd.12867 BindingDB Entry DOI: 10.7270/Q25M64KX | |||||||||||
More data for this Ligand-Target Pair |