BDBM223198 N-[3'-(1,1-Dioxido-4-oxo-1,2,5-thiadiazolidin-2-yl)-4'-methyl[1,1'-biphenyl]-4-yl]acetamide (5b)

SMILES: CC(=O)Nc1ccc(cc1)-c1ccc(C)c(c1)N1CC(=O)NS1(=O)=O

InChI Key: InChIKey=IUUBXSDHTIURGZ-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223198   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein tyrosine phosphatase 1B (PTP1B) (Homo sapiens (Human))	BDBM223198 (N-[3'-(1,1-Dioxido-4-oxo-1,2,5-thiadiazolidin-...) Show SMILES CC(=O)Nc1ccc(cc1)-c1ccc(C)c(c1)N1CC(=O)NS1(=O)=O Show InChI InChI=1S/C17H17N3O4S/c1-11-3-4-14(13-5-7-15(8-6-13)18-12(2)21)9-16(11)20-10-17(22)19-25(20,23)24/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.20E+4	n/a	6.40E+4	n/a	n/a	n/a	n/a	7.0	n/a
University of Missouri					Assay Description Assays for the reversible inhibition of PTP1B (72 nM) contained the test compound(2a, 2b, 5a, or 5b) in Bis-Tris (50 mM), NaCl (100 mM), EDTA (2 mM),...				Biochemistry 56: 2051-2060 (2017) Article DOI: 10.1021/acs.biochem.7b00151 BindingDB Entry DOI: 10.7270/Q2HX1BJ8
					More data for this Ligand-Target Pair