BDBM223286 (2-(1H-Tetrazol-5-yl)cyclopropyl)(5-((cyclopropylmethyl)(4-fluoronaphthalen-1-yl)amino)-3-methoxypyridin-2-yl)methanone::US20160326143, 61::US9657001, 61
SMILES: COc1cc(cnc1C(=O)C1CC1c1nnn[nH]1)N(CC1CC1)c1ccc(F)c2ccccc12
InChI Key:
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Leukotriene C4 synthase (Homo sapiens (Human)) | BDBM223286 ((2-(1H-Tetrazol-5-yl)cyclopropyl)(5-((cyclopropylm...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va... | US Patent US9657001 (2017) BindingDB Entry DOI: 10.7270/Q2SJ1NPG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leukotriene C4 synthase (Homo sapiens (Human)) | BDBM223286 ((2-(1H-Tetrazol-5-yl)cyclopropyl)(5-((cyclopropylm...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 39 | n/a | n/a | n/a | n/a | 7.8 | n/a |
Astrazeneca Ab US Patent | Assay Description In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic... | US Patent US20160326143 (2016) BindingDB Entry DOI: 10.7270/Q2W66JN5 | |||||||||||
More data for this Ligand-Target Pair |