BDBM223981 6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine::A-196 (3)
SMILES: Clc1cc2c(NC3CCCC3)nnc(-c3ccncc3)c2cc1Cl
InChI Key: InChIKey=ABGOSOMRWSYAOB-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein lysine methyltransferase SUV4-20H2 (SUV4-20H2) (Homo sapiens (Human)) | BDBM223981 (6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthala...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 144 | n/a | n/a | n/a | n/a | 8.0 | 25 |
AbbVie | Assay Description Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ... | Nat Chem Biol 13: 317-324 (2017) Article DOI: 10.1038/nchembio.2282 BindingDB Entry DOI: 10.7270/Q2X065XF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein lysine methyltransferase SUV4-20H1 (SUV4-20H1) (Homo sapiens (Human)) | BDBM223981 (6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthala...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | 8.0 | 25 |
AbbVie | Assay Description Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ... | Nat Chem Biol 13: 317-324 (2017) Article DOI: 10.1038/nchembio.2282 BindingDB Entry DOI: 10.7270/Q2X065XF | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |