BDBM224012 Capzimin::US10005735, Compound 12
SMILES: Sc1cccc2cc(cnc12)C(=O)NCCc1nccs1
InChI Key: InChIKey=MYNGHZGMRXNEEH-UHFFFAOYSA-N
Data: 12 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
26S Proteasome regulatory subunit Rpn11 (Rpn11) (Homo sapiens (Human)) | BDBM224012 (Capzimin | US10005735, Compound 12) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 340 | n/a | n/a | n/a | n/a | 7.5 | 30 |
California Institute of Technology | Assay Description Fluorescence polarization assays were performed in low-volume 384-well solid black plates (Molecular Devices) in quadruplicate. The assays were perfo... | Nat Chem Biol 13: 486-493 (2017) Article DOI: 10.1038/nchembio.2326 BindingDB Entry DOI: 10.7270/Q24J0D0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
COP9 signalosome complex subunit 5 (Csn5) (Homo sapiens (Human)) | BDBM224012 (Capzimin | US10005735, Compound 12) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
California Institute of Technology | Assay Description Csn5 activity was measured using purified CSN complex and the fluorescent substrate OGNedd8SCFSkp2, in which a unique cysteine engineered into ... | Nat Chem Biol 13: 486-493 (2017) Article DOI: 10.1038/nchembio.2326 BindingDB Entry DOI: 10.7270/Q24J0D0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
STAM-binding protein (AMSH) (Homo sapiens (Human)) | BDBM224012 (Capzimin | US10005735, Compound 12) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
California Institute of Technology | Assay Description AMSH activity was measured using 10 nM purified AMSH (E-548B, Boston Biochem) and 80 nM di-ubiquitin substrate DiUbK63TAMRA (UF-310, Boston Biochem).... | Nat Chem Biol 13: 486-493 (2017) Article DOI: 10.1038/nchembio.2326 BindingDB Entry DOI: 10.7270/Q24J0D0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BRISC complex (Homo sapiens (Human)) | BDBM224012 (Capzimin | US10005735, Compound 12) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
California Institute of Technology | Assay Description BRCC36 activity was measured using 1 nM purified BRISC complex and 80 nM di-ubiquitin substrate DiUbK63TAMRA (UF-310, Boston Biochem). TAMRA fluoresc... | Nat Chem Biol 13: 486-493 (2017) Article DOI: 10.1038/nchembio.2326 BindingDB Entry DOI: 10.7270/Q24J0D0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cereblon/Histone deacetylase 6 (Homo sapiens (Human)) | BDBM224012 (Capzimin | US10005735, Compound 12) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 37 |
California Institute of Technology | Assay Description The enzyme was diluted with 25 mM Tris-Cl, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 0.1 mg/ml BSA, pH 8.0 buffer and its activity was measured by using S... | Nat Chem Biol 13: 486-493 (2017) Article DOI: 10.1038/nchembio.2326 BindingDB Entry DOI: 10.7270/Q24J0D0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMSH-like protease (Homo sapiens (Human)) | BDBM224012 (Capzimin | US10005735, Compound 12) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i... | Bioorg Med Chem 17: 8086-92 (2009) BindingDB Entry DOI: 10.7270/Q22R3V09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-12 (MMP12) (Homo sapiens (Human)) | BDBM224012 (Capzimin | US10005735, Compound 12) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
California Institute of Technology | Assay Description The assay was carried out in white NUNC 96-well plates as previously described [Puerta et al., J. Biol. Inorg. Chem., 11:131-138]. Each well containe... | Nat Chem Biol 13: 486-493 (2017) Article DOI: 10.1038/nchembio.2326 BindingDB Entry DOI: 10.7270/Q24J0D0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM224012 (Capzimin | US10005735, Compound 12) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 8.0 | 25 |
California Institute of Technology | Assay Description Assays were run in 50 mM HEPES (pH 8.0). A BioTek Synergy H4 microplate sample processor was used. The compounds were incubated with protein (final c... | Nat Chem Biol 13: 486-493 (2017) Article DOI: 10.1038/nchembio.2326 BindingDB Entry DOI: 10.7270/Q24J0D0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glyoxalase 1 (GLO1) (Homo sapiens (Human)) | BDBM224012 (Capzimin | US10005735, Compound 12) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.28E+4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
California Institute of Technology | Assay Description Assays were carried out in 100 mM sodium phosphate, pH 7.0 buffer using 96-well Clear UV Plate (Corning UV Transparent Microplates; catalog #3635). A... | Nat Chem Biol 13: 486-493 (2017) Article DOI: 10.1038/nchembio.2326 BindingDB Entry DOI: 10.7270/Q24J0D0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
26S Proteasome regulatory subunit Rpn11 (Rpn11) (Homo sapiens (Human)) | BDBM224012 (Capzimin | US10005735, Compound 12) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i... | Bioorg Med Chem 17: 8086-92 (2009) BindingDB Entry DOI: 10.7270/Q22R3V09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
COP9 signalosome complex subunit 5 (Csn5) (Homo sapiens (Human)) | BDBM224012 (Capzimin | US10005735, Compound 12) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i... | Bioorg Med Chem 17: 8086-92 (2009) BindingDB Entry DOI: 10.7270/Q22R3V09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM224012 (Capzimin | US10005735, Compound 12) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
California Institute of Technology | Assay Description The assay was carried out in white NUNC 96-well plates as previously described [Puerta et al., J. Biol. Inorg. Chem., 11:131-138]. Each well containe... | Nat Chem Biol 13: 486-493 (2017) Article DOI: 10.1038/nchembio.2326 BindingDB Entry DOI: 10.7270/Q24J0D0B | |||||||||||
More data for this Ligand-Target Pair |