BDBM22532 4-Benzyl-1H-imidazole derivative, 13::4-benzyl-1H-imidazole
SMILES: C(c1cnc[nH]1)c1ccccc1
InChI Key: InChIKey=HREUGOAZLRNTEM-UHFFFAOYSA-N
Data: 2 KI
PDB links: 7 PDB IDs contain this monomer as substructures. 7 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Trace amine-associated receptor 1 (Homo sapiens (Human)) | BDBM22532 (4-Benzyl-1H-imidazole derivative, 13 | 4-benzyl-1H...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of (S)-4-(2,4-difluorophenyl-3-tritio) -4,5-dihydro-2-oxazolamine from human TAAR1 receptor expressed in HEK293 cells after 90 mins by b... | Bioorg Med Chem Lett 22: 5244-8 (2012) Article DOI: 10.1016/j.bmcl.2012.06.060 BindingDB Entry DOI: 10.7270/Q2W0973B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM22532 (4-Benzyl-1H-imidazole derivative, 13 | 4-benzyl-1H...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 162 | -9.26 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
VU University Amsterdam | Assay Description Ligand displacement assays were performed on CHO cells membranes expressing hH3R. Retained radioactivity was determined by liquid scintillation count... | J Med Chem 51: 2944-53 (2008) Article DOI: 10.1021/jm7014149 BindingDB Entry DOI: 10.7270/Q24F1P2W | |||||||||||
More data for this Ligand-Target Pair |