BDBM22542 4-(1H-imidazol-4-ylmethyl)piperidine::4-(1H-imidazol-5-ylmethyl)piperidine::IMMEPIP::Immepip
SMILES: C(C1CCNCC1)c1cnc[nH]1
InChI Key: InChIKey=MCNGUYXRBCIGOV-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H3 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Meiji Seika Kaisha, Ltd Curated by ChEMBL | Assay Description Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation... | Bioorg Med Chem 18: 5441-8 (2010) Article DOI: 10.1016/j.bmc.2010.04.052 BindingDB Entry DOI: 10.7270/Q2C82B88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Meiji Seika Kaisha, Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation counting | J Med Chem 53: 6445-56 (2010) Article DOI: 10.1021/jm100643t BindingDB Entry DOI: 10.7270/Q2QF8T3X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HRH3 (GUINEA PIG) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Schering Plough Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in guinea pig brain | Bioorg Med Chem Lett 16: 395-9 (2005) Article DOI: 10.1016/j.bmcl.2005.09.076 BindingDB Entry DOI: 10.7270/Q29S1QK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by PDSP Ki Database | Mol Pharmacol 59: 420-6 (2001) Article DOI: 10.1124/mol.59.3.420 BindingDB Entry DOI: 10.7270/Q26Q1VSR | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 0.407 | -12.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
VU University Amsterdam | Assay Description Ligand displacement assays were performed on CHO cells membranes expressing hH3R. Retained radioactivity was determined by liquid scintillation count... | J Med Chem 51: 2944-53 (2008) Article DOI: 10.1021/jm7014149 BindingDB Entry DOI: 10.7270/Q24F1P2W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HRH3 (RAT) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP Ki Database | J Pharmacol Exp Ther 293: 771-8 (2000) BindingDB Entry DOI: 10.7270/Q2348HX8 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Amsterdam | Assay Description Ligand displacement assays were performed on The SK-N-MC/hH3R cell homogenates. Retained radioactivity was determined by liquid scintillation countin... | J Pharmacol Exp Ther 314: 1310-21 (2005) Article DOI: 10.1124/jpet.105.087965 BindingDB Entry DOI: 10.7270/Q2KD1W6V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting | J Med Chem 54: 8136-47 (2011) Article DOI: 10.1021/jm201042n BindingDB Entry DOI: 10.7270/Q2MW2JDX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HRH3 (RAT) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | PubMed | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP Ki Database | J Pharmacol Exp Ther 293: 771-8 (2000) BindingDB Entry DOI: 10.7270/Q2348HX8 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | PubMed | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP Ki Database | J Pharmacol Exp Ther 293: 771-8 (2000) BindingDB Entry DOI: 10.7270/Q2348HX8 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by PDSP Ki Database | Mol Pharmacol 59: 420-6 (2001) Article DOI: 10.1124/mol.59.3.420 BindingDB Entry DOI: 10.7270/Q26Q1VSR | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 19.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting | J Med Chem 54: 8136-47 (2011) Article DOI: 10.1021/jm201042n BindingDB Entry DOI: 10.7270/Q2MW2JDX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Amsterdam | Assay Description Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin... | J Pharmacol Exp Ther 314: 1310-21 (2005) Article DOI: 10.1124/jpet.105.087965 BindingDB Entry DOI: 10.7270/Q2KD1W6V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Meiji Seika Kaisha, Ltd Curated by ChEMBL | Assay Description Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting | Bioorg Med Chem 18: 5441-8 (2010) Article DOI: 10.1016/j.bmc.2010.04.052 BindingDB Entry DOI: 10.7270/Q2C82B88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 Receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Meiji Seika Kaisha, Ltd Curated by ChEMBL | Assay Description Displacement of [125I]aminopotentidine from human histamine H2 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting | Bioorg Med Chem 18: 5441-8 (2010) Article DOI: 10.1016/j.bmc.2010.04.052 BindingDB Entry DOI: 10.7270/Q2C82B88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
R.W. Johnson Pharmaceutical Research Institute Curated by PDSP Ki Database | Mol Pharmacol 55: 1101-7 (1999) BindingDB Entry DOI: 10.7270/Q2DR2T2H | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a |
Meiji Seika Kaisha, Ltd Curated by ChEMBL | Assay Description Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil... | Bioorg Med Chem 18: 5441-8 (2010) Article DOI: 10.1016/j.bmc.2010.04.052 BindingDB Entry DOI: 10.7270/Q2C82B88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 15.8 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Agonist activity at human histamine H4 receptor | J Med Chem 54: 26-53 (2011) Article DOI: 10.1021/jm100064d BindingDB Entry DOI: 10.7270/Q2VQ33RV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM22542 (4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a |
Meiji Seika Kaisha, Ltd. Curated by ChEMBL | Assay Description Agonist activity at human histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding | J Med Chem 53: 6445-56 (2010) Article DOI: 10.1021/jm100643t BindingDB Entry DOI: 10.7270/Q2QF8T3X | |||||||||||
More data for this Ligand-Target Pair |