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BDBM22553 2-[3-(1H-imidazol-4-ylmethyl)phenyl]-5,5-dimethyl-5,6-dihydro-4H-1,3-oxazine::4-Benzyl-1H-imidazole derivative, 31

SMILES: CC1(C)COC(=NC1)c1cccc(Cc2cnc[nH]2)c1

InChI Key: InChIKey=ZPBNADIRZNHTBQ-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 22553   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM22553
PNG
(2-[3-(1H-imidazol-4-ylmethyl)phenyl]-5,5-dimethyl-...)
Show SMILES CC1(C)COC(=NC1)c1cccc(Cc2cnc[nH]2)c1 |c:5|
Show InChI InChI=1S/C16H19N3O/c1-16(2)9-18-15(20-10-16)13-5-3-4-12(6-13)7-14-8-17-11-19-14/h3-6,8,11H,7,9-10H2,1-2H3,(H,17,19)
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PC cid
PC sid
UniChem
Article
PubMed
2.51E+3 -7.63n/an/an/an/an/a7.425



VU University Amsterdam



Assay Description
Ligand displacement assays were performed on CHO cells membranes expressing hH3R. Retained radioactivity was determined by liquid scintillation count...


J Med Chem 51: 2944-53 (2008)


Article DOI: 10.1021/jm7014149
BindingDB Entry DOI: 10.7270/Q24F1P2W
More data for this
Ligand-Target Pair